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SINGLE-CELL CULTURE AND SEQUENCING WITH LIPID-MODIFIED OLIGOS
SINGLE-CELL CULTURE AND SEQUENCING WITH LIPID-MODIFIED OLIGOS
Researchers at UCSF have developed methods for sequencing a single cell from a cell culture sample and obtaining morphologic or phenotypic measurements and information by combining sequencing approaches and spatial hashing (e.g. barcoding) at a single cell level.
There exists a need in...
Published: 7/27/2023
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Inventor(s): Kai-Chun Chang, Adam Abate
Keywords(s): Lipid-Modified, Oligonucleotides, Sequencing, Single Cell
Category(s): Technology Classifications > Biology
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NUCLEAR DNA-ANTIBODY SEQUENCING FOR JOINT PROFILING OF GENOTYPE AND PROTEIN IN SINGLE NUCLEI
NUCLEAR DNA-ANTIBODY SEQUENCING FOR JOINT PROFILING OF GENOTYPE AND PROTEIN IN SINGLE NUCLEI
Researchers at UCSF have developed a method for joint nucleic acid-protein profiling from single nuclei that can be applied to all manner of biological samples, including frozen tumor specimens or infectious disease samples.
Cellular heterogeneity is an aspect...
Published: 5/18/2023
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Inventor(s): Harish Vasudevan, Benjamin Demaree, Cyrille Delley, Adam Abate
Keywords(s): Antibody, Frozen Specimens, Genotyping, Nuclei, Nucleic Acid, Phenotyping, Protein, Single Cell
Category(s): Technology Classifications > Biology
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METHOD FOR COMBINED GENOME METHYLATION AND VARIATION ANALYSES
METHOD FOR COMBINED GENOME METHYLATION AND VARIATION ANALYSES
Researchers at Stanford have developed improved methods for combined analyses of epigenetics and nucleotide variation in single cells.
Single cell genomic sequencing has allowed characterization of the diversity and evolution of cells within tissues. Recent advances in whole genome...
Published: 3/17/2023
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Inventor(s): Veronica Gonzalez-Pena, Charles Gawad
Keywords(s): Biomolecules, Epigenetics, Methylation, Single Cell, Single Cell Analysis, Single Cell Genomics
Category(s): Technology Classifications > Biology
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SPATIAL GENOMICS WITH SINGLE CELL RESOLUTION
SPATIAL GENOMICS WITH SINGLE CELL RESOLUTION
Researchers at UCSF have developed methods for in situ labelling and sequencing to obtain spatial information and multiomics analysis at a single cell level.
Single-cell sequencing has revealed unappreciated cellular diversity in many ostensibly homogeneous systems and led to an ongoing scientific...
Published: 7/5/2023
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Inventor(s): Cyrille Delley, Adam Abate
Keywords(s): Single Cell, Single Cell Analysis, Single Cell Genomics, Single Cell RNA Sequencing, Single-cell Transcriptomics
Category(s): Technology Classifications > Biology
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QUANTIFICATION OF CELLULAR PROTEINS USING BARCODED BINDING MOIETIES
QUANTIFICATION OF CELLULAR PROTEINS USING BARCODED BINDING MOIETIES
Researchers at Stanford have developed a method enabling quantification of intracellular protein levels using oligonucleotide-barcoded antibodies.
Multiplexing single cell technologies affords researchers the ability to characterize cell states and identify gene regulatory programs...
Published: 3/17/2023
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Inventor(s): William Greenleaf, Amy Chen
Keywords(s): Affinity Reagent, Antibody, Biomolecules, Integrated Screening System, ScRNA-seq, Single Cell, Single Cell Analysis, Single Cell Genomics, Single Cell RNA Sequencing, Single-cell Transcriptomics
Category(s): Technology Classifications > Biology
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MICROFLUIDIC CELL BARCODING AND SEQUENCING
MICROFLUIDIC CELL BARCODING AND SEQUENCING
Researchers at UC Berkeley have developed µCB-seq, a microfluidic cell barcoding and sequencing platform for high-resolution imaging and sequencing of single cells.
Single-cell RNA sequencing (scRNA-seq) enables the investigation of complex biological processes in multicellular organisms with high...
Published: 3/17/2023
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Inventor(s): Aaron Streets, Tyler Chen, Anushka Gupta
Keywords(s): Fluorescence, Genetic Dissection, Microfluidics, ScRNA-seq, Single Cell, Single Cell Analysis, Single Cell Genomics, Single Cell RNA Sequencing, Single-cell Transcriptomics
Category(s): Technology Classifications > Biology
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IMAGING AND SEQUENCING PROTEIN-DNA INTERACTIONS IN SINGLE CELLS USING INTEGRATED MICROFLUIDICS
IMAGING AND SEQUENCING PROTEIN-DNA INTERACTIONS IN SINGLE CELLS USING INTEGRATED MICROFLUIDICS
Researchers at UC Berkeley have developed an integrated microfluidics method, µDamID (microfluidic DamID), capable of co-determining the cellular location and nucleotide sequence of DNA that is contacted by a protein of interest in a single cell.
Genome...
Published: 3/17/2023
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Inventor(s): Aaron Streets, Nicolas Altemose
Keywords(s): Fluorescence, Genetic Dissection, Microfluidics, Optical Probe, Single Cell, Single Cell Analysis
Category(s): Technology Classifications > Biology
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METHODS, COMPOSITIONS, AND KITS FOR ASSESSING ENDOMETRIAL TRANSFORMATION
METHODS, COMPOSITIONS, AND KITS FOR ASSESSING ENDOMETRIAL TRANSFORMATION
Researchers at Stanford and the Chan Zuckerberg Biohub have developed a transcriptomic characterization of human endometrium and identified specific gene signatures for use in evaluating endometrial samples for one or more menstrual cycle events.
In a human menstrual cycle,...
Published: 11/29/2023
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Inventor(s): Stephen Quake, Carlos Simon, Wanxin Wang, Felipe Viella
Keywords(s): Diagnosis, Single Cell, Single Cell RNA Sequencing, Single-cell Transcriptomics
Category(s): Technology Classifications > Biology
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SCITO-SEQ: SINGLE CELL COMBINATORIAL INDEXED CYTOMETRY SEQUENCING
SCITO-SEQ: SINGLE CELL COMBINATORIAL INDEXED CYTOMETRY SEQUENCING
Researchers at UCSF have developed SCITO-seq, a new workflow for single cell sequencing-based proteomics.
The use of DNA to barcode and tag antibodies has created new opportunities to use sequencing to profile the molecular properties of thousands of cells simultaneously. Furthermore,...
Published: 1/19/2024
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Inventor(s): Chun Ye, Byungjin Hwang, David Lee
Keywords(s): Antibody, Droplet-Based Single Cell Sequencing, dsc-Seq, Microfluidics, Proteomics, Single Cell, Single Cell Analysis
Category(s): Technology Classifications > Biology
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MULTI-PARAMETRIC SINGLE CELL ANALYSIS USING SPECTRALLY ENCODED MICROBEADS
MULTI-PARAMETRIC SINGLE CELL ANALYSIS USING SPECTRALLY ENCODED MICROBEADS
Researchers at Stanford and the Chan Zuckerberg Biohub have developed methods for multiple parameter single cell analysis.
Methods to analyze single cells are important for evaluating cell-to-cell variability in biological systems, especially where the characteristics of minority...
Published: 3/17/2023
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Inventor(s): Polly Fordyce, Kara Brower, Alexandera Sockell, Adam White, Yinnian Feng
Keywords(s): Biomolecules, Fluorescence, Microfluidics, RNA-seq, ScRNA-seq, Single Cell, Single Cell Analysis
Category(s): Technology Classifications > Biology
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