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MICROFLUIDIC CELL BARCODING AND SEQUENCING
MICROFLUIDIC CELL BARCODING AND SEQUENCING
Researchers at UC Berkeley have developed µCB-seq, a microfluidic cell barcoding and sequencing platform for high-resolution imaging and sequencing of single cells.
Single-cell RNA sequencing (scRNA-seq) enables the investigation of complex biological processes in multicellular organisms with high...
Published: 3/17/2023
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Inventor(s): Aaron Streets, Tyler Chen, Anushka Gupta
Keywords(s): Fluorescence, Genetic Dissection, Microfluidics, ScRNA-seq, Single Cell, Single Cell Analysis, Single Cell Genomics, Single Cell RNA Sequencing, Single-cell Transcriptomics
Category(s): Technology Classifications > Biology
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IMAGING AND SEQUENCING PROTEIN-DNA INTERACTIONS IN SINGLE CELLS USING INTEGRATED MICROFLUIDICS
IMAGING AND SEQUENCING PROTEIN-DNA INTERACTIONS IN SINGLE CELLS USING INTEGRATED MICROFLUIDICS
Researchers at UC Berkeley have developed an integrated microfluidics method, µDamID (microfluidic DamID), capable of co-determining the cellular location and nucleotide sequence of DNA that is contacted by a protein of interest in a single cell.
Genome...
Published: 3/17/2023
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Inventor(s): Aaron Streets, Nicolas Altemose
Keywords(s): Fluorescence, Genetic Dissection, Microfluidics, Optical Probe, Single Cell, Single Cell Analysis
Category(s): Technology Classifications > Biology
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NOVEL UBIQUITOUS CHROMATIN-OPENING ELEMENT FOR STABLE LONG-TERM TRANSGENE EXPRESSION
NOVEL UBIQUITOUS CHROMATIN-OPENING ELEMENT FOR STABLE LONG-TERM TRANSGENE EXPRESSION
Researchers at Stanford and the Chan Zuckerberg Biohub have identified a novel chromatin remodeling element for stable long-term transgene expression.
Gene therapy applications and biomanufacturing of therapeutic proteins require stable long-term transgene expression....
Published: 3/17/2023
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Inventor(s): Christina Smolke, Shireen Rudina
Keywords(s): Chromatin Remodeling, Genetic Dissection, Genome Integration, Transgene
Category(s): Technology Classifications > Biology
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ENABLING GENETIC ANALYSIS OF DIVERSE BACTERIA WITH MOBILE-CRISPRi
ENABLING GENETIC ANALYSIS OF DIVERSE BACTERIA WITH MOBILE-CRISPRi
Researchers at UCSF, funded in part by the Chan Zuckerberg Biohub, have generated a modular and effective CRISPRi system for the genetic dissection of non-model bacteria.
The vast majority of bacteria, including human pathogens and microbiome species, lack genetic tools needed to associate...
Published: 3/17/2023
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Inventor(s): Jason Peters, Carol Gross, Oren Rosenberg
Keywords(s): Bacterial Pathogenesis, CRISPRi, Genetic Dissection, Genome Integration, Non-Model Bacteria
Category(s): Technology Classifications > Biology
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