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­NON-INVASIVE PROFILING OF URINARY TRACT TISSUES WITH URINE LIQUID BIOPSY
­NON-INVASIVE PROFILING OF URINARY TRACT TISSUES WITH URINE LIQUID BIOPSY Researchers at Stanford and UCSFhave determined methods of performing cell-free RNA (cfRNA) transcriptomics and metabolomics on urine samples. Urine is assayed alongside blood in medicine, however current clinical diagnostic tests exploit only a minor fraction of its biomolecular...
Published: 2/14/2024   |   Inventor(s): Sevahn Vorperian, Stephen Quake, Gabriel Loeb
Keywords(s): Biopsy, cfRNA, Liquid, Urine
Category(s): Technology Classifications > Biology
­GENERATION OF ANTIGEN-SPECIFIC T AND B CELLS USING ENGINEERED COMMENSALS
­GENERATION OF ANTIGEN-SPECIFIC T AND B CELLS USING ENGINEERED COMMENSALS Researchers at Stanford have developed methods to link antigenic or immunomodulatory molecules to bacterial surface proteins of commensal bacteria that result in a high immune response when applied to an epithelial surface of a mammal. Commensal microbiota reside primarily...
Published: 2/14/2024   |   Inventor(s): Michael Fischbach, Djenet Bousbaine, Christopher Barnes, Katherine Bauman, Yasmine Belkaid
Keywords(s): Antigen, Bacteria, Immunomodulator
Category(s): Technology Classifications > Biology
­CELL-PENETRATING PEPTIDES FOR NUCLEIC ACID AND PROTEIN DELIVERY IN PLANTS
­CELL-PENETRATING PEPTIDES FOR NUCLEIC ACID AND PROTEIN DELIVERY IN PLANTS Researchers at UC Berkeley have developed methods to deliver biomolecules to plant cells using new plant-derived cell penetrating peptides (CPPs). Despite the revolution in DNA editing that the last decade has brought, plant genetic engineering has not been able to benefit...
Published: 2/14/2024   |   Inventor(s): Markita Landry, Jeffrey Wang, Henry Squire
Keywords(s): Cell Wall, Delivery Method, Plant
Category(s): Technology Classifications > Biology
MANIPULATING SPATIAL RNA LOCALIZATION
­MANIPULATING SPATIAL RNA LOCALIZATION Researchers at Stanford have developed an inducible and programmable CRISPR-mediated transcript organization (CRISPR-TO) method for repositioning RNAs to various desired subcellular compartments. Spatial RNA transcriptomics, including subcellular mRNA localization, is a core mechanism for spatiotemporal regulation...
Published: 2/14/2024   |   Inventor(s): Lei Qi, Mengting Han
Keywords(s): Localization, mRNA, Neuron
Category(s): Technology Classifications > Biology
­DESIGN OF A UNIVERSAL INFLUENZA VACCINE CANDIDATES VIA ANTIGEN REORIENTATION
­DESIGN OF A UNIVERSAL INFLUENZA VACCINE CANDIDATES VIA ANTIGEN REORIENTATION Researchers at Stanford have developed a novel universal influenza vaccine candidate. Vaccines are a major feat of biomedical innovation. Successful vaccines produce broad humoral immunity to a pathogen to prevent subsequent infection. In this vein, adjuvants are compounds...
Published: 12/5/2023   |   Inventor(s): Duo Xu, Peter Kim
Keywords(s): Adjuvant, Alum, Infectious Disease, Vaccine
Category(s): Technology Classifications > Biology
­PROBE-BASED DEVICE-FREE SINGLE-CELL RNA PROFILING
­PROBE-BASED DEVICE-FREE SINGLE-CELL RNA PROFILING Researchers at UCSF have developed a novel method for probe-based scRNA-seq. Single cell RNA sequencing (scRNA-seq) has revolutionized the field of cell biology by enabling nucleic acid profiling at single cell resolution. Typical detection efficiency of scRNA-seq ranges between 5-45%, mostly...
Published: 12/5/2023   |   Inventor(s): Bo Huang, Daniel Foyt
Keywords(s): Barcoding, RNA Sequencing, ScRNA-seq
Category(s): Technology Classifications > Biology
­METHODS AND COMPOSITIONS IN PROGRAMMABLE RECEPTOR FOR ANTIGEN DETECTION AND CUSTOMIZED CELL RESPONSES
­METHODS AND COMPOSITIONS IN PROGRAMMABLE RECEPTOR FOR ANTIGEN DETECTION AND CUSTOMIZED CELL RESPONSES Researchers at Stanford have developed new methods to create programmable synthetic receptors (PAGER). The advent of programmable synthetic receptors represents a new era in cellular therapies and in biomedical science. There are currently tens...
Published: 12/5/2023   |   Inventor(s): Nicholas Kalogriopoulos, Alice Ting, Matthew Ravalin, Reika Tei
Keywords(s): Antibody, Fusion Protein, Receptor
Category(s): Technology Classifications > Biology
­COMPOUNDS AS GABA RECEPTOR MODULATORS
­COMPOUNDS AS GABA RECEPTOR MODULATORS Researchers at UCSF have developed novel GABA-modulating pharmaceutical compounds that are potential therapeutics for the treatment of chronic pain. Neurotransmitters are the building blocks of information transfer in the central nervous system and can modulate action potentials at the synapses of neurons...
Published: 12/5/2023   |   Inventor(s): Matthew McCarroll, Jason Sello, David Kokel, Allan Basbaum, Jarret Weinrich
Keywords(s): Inhibitor, Neuron, Pain
Category(s): Technology Classifications > Biology
­HUMAN CENTRAL NERVOUS SYSTEM (CNS) TARGETING AAV VARIANTS
­HUMAN CENTRAL NERVOUS SYSTEM (CNS) TARGETING AAV VARIANTS Researchers at UCSF and UC Berkeley have developed a recombinant adeno-associated virus (rAAV) with an altered capsid protein, where the rAAV exhibits greater ability to infect a central nervous system cell compared to wild-type AAVs. The central nervous system (CNS) comprises a multitude...
Published: 10/26/2023   |   Inventor(s): Tomasz Nowakowski, Galina Popava (Schmunk), David Schaffer, Danqing Zhu
Keywords(s): Adeno-associated Virus, Brain, Neuron
Category(s): Technology Classifications > Biology
­GERMLINE AND CANCER SUBTYPES FOR MONITORING AND TREATMENT
­GERMLINE AND CANCER SUBTYPES FOR MONITORING AND TREATMENT Researchers at Stanford have developed practical applications that use germline information (e.g., germline epitope burden) for diagnosis, monitoring and treatment of cancer. Cancer represents a wide spectrum of molecularly and morphologically diverse diseases. Individuals with the same...
Published: 10/26/2023   |   Inventor(s): Christina Curtis, Kathleen Houlahan
Keywords(s): Cancer, Immunotherapy
Category(s): Technology Classifications > Biology
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