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METHOD FOR MASSIVELY PARALLEL SCREENING OF APTAMER SWITCHES
METHOD FOR MASSIVELY PARALLEL SCREENING OF APTAMER SWITCHES
Researchers at Stanford have developed a massively parallel screening strategy to screen for target-responsive molecular switches.
Target-responsive RNA- and DNA-based molecular switches have potential utility in a variety of technological applications. Such biosensors are typically...
Published: 3/17/2023
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Inventor(s): Hyongsok Soh
Keywords(s): Affinity Reagent, Aptamer, Base-Modified Nucleotide, Biomolecules, Biosensor System, Fluorescence, High-Throughput, Integrated Screening System, Molecular Switches, Non-Natural Nucleotide
Category(s): Technology Classifications > Biology
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METHOD AND SYSTEM FOR MULTI-VIEW EPISCOPIC SELECTIVE PLANE ILLUMINATION MICROSCOPE
METHOD AND SYSTEM FOR MULTI-VIEW EPISCOPIC SELECTIVE PLANE ILLUMINATION MICROSCOPE
Researchers at the Chan Zuckerberg Biohub have developed a single objective, multi-view light-sheet microscope with increased imaging depth and resolution.
Light-sheet microscopy, a type of selective plane illumination microscopy (SPIM), is an essential imaging...
Published: 3/17/2023
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Inventor(s): Bin Yang, Loic Royer
Keywords(s): Fluorescence, High-Throughput
Category(s): Technology Classifications > Engineering
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POPTAG: A MODULAR PLATFORM FOR ENGINEERING FUNCTION OF NATURAL AND SYNTHETIC BIOMOLECULAR CONDENSATES
POPTAG: A MODULAR PLATFORM FOR ENGINEERING FUNCTION OF NATURAL AND SYNTHETIC BIOMOLECULAR CONDENSATES
Researchers at Stanford have developed a protein, PopTag, that drives phase separation when it is part of a chimeric fusion protein.
Biomolecular condensation is a powerful mechanism underlying cellular organization and regulation in cell physiology...
Published: 3/17/2023
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Inventor(s): Lucy Shapiro, Keren Lasker, Steven Boeynaems, Aaron Gitler
Keywords(s): Biomolecules, Fluorescence
Category(s): Technology Classifications > Biology
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POINT-OF-CARE AND IMPROVED DETECTION AND QUANTIFICATION OF BIOMOLECULES
POINT-OF-CARE AND IMPROVED DETECTION AND QUANTIFICATION OF BIOMOLECULES
Researchers at UCSF and the Chan Zuckerberg Biohub have developed a workflow for accurate bulk quantitation of droplet digital PCR, which can be used in point-of-care clinical settings with minimal sample processing.
The quantitation of nucleic acids is important for clinical...
Published: 3/17/2023
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Inventor(s): Adam Abate, Xiangpeng Li
Keywords(s): Biomolecules, Diagnosis, Droplet Digital PCR, Fluorescence, High-Throughput, Microfluidics, SARS-CoV-2
Category(s): Technology Classifications > Biology
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MICROFLUIDIC CELL BARCODING AND SEQUENCING
MICROFLUIDIC CELL BARCODING AND SEQUENCING
Researchers at UC Berkeley have developed µCB-seq, a microfluidic cell barcoding and sequencing platform for high-resolution imaging and sequencing of single cells.
Single-cell RNA sequencing (scRNA-seq) enables the investigation of complex biological processes in multicellular organisms with high...
Published: 3/17/2023
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Inventor(s): Aaron Streets, Tyler Chen, Anushka Gupta
Keywords(s): Fluorescence, Genetic Dissection, Microfluidics, ScRNA-seq, Single Cell, Single Cell Analysis, Single Cell Genomics, Single Cell RNA Sequencing, Single-cell Transcriptomics
Category(s): Technology Classifications > Biology
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IMAGING AND SEQUENCING PROTEIN-DNA INTERACTIONS IN SINGLE CELLS USING INTEGRATED MICROFLUIDICS
IMAGING AND SEQUENCING PROTEIN-DNA INTERACTIONS IN SINGLE CELLS USING INTEGRATED MICROFLUIDICS
Researchers at UC Berkeley have developed an integrated microfluidics method, µDamID (microfluidic DamID), capable of co-determining the cellular location and nucleotide sequence of DNA that is contacted by a protein of interest in a single cell.
Genome...
Published: 3/17/2023
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Inventor(s): Aaron Streets, Nicolas Altemose
Keywords(s): Fluorescence, Genetic Dissection, Microfluidics, Optical Probe, Single Cell, Single Cell Analysis
Category(s): Technology Classifications > Biology
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MULTIPLEXED DETECTION AND CHARACTERIZATION OF MICROBIAL NUCLEIC ACIDS USING SPECTRALLY ENCODED BEADS
MULTIPLEXED DETECTION AND CHARACTERIZATION OF MICROBIAL NUCLEIC ACIDS USING SPECTRALLY ENCODED BEADS
Researchers at Stanford and the Chan Zuckerberg Biohub have developed a platform for characterizing a population of microbes using spectrally encoded beads.
The clinical treatment of microbial infections is dependent on the proper identification and...
Published: 3/17/2023
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Inventor(s): Adam White, Huy Nguyen, Feiqiao Yu, Tyler Shimko, Polly Fordyce, Nadya Andini, Samuel Yang
Keywords(s): Blood, Diagnosis, Fluorescence, Microbe, Microfluidics, Nucleic Acid, RNA-seq
Category(s): Technology Classifications > Biology
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MULTI-PARAMETRIC SINGLE CELL ANALYSIS USING SPECTRALLY ENCODED MICROBEADS
MULTI-PARAMETRIC SINGLE CELL ANALYSIS USING SPECTRALLY ENCODED MICROBEADS
Researchers at Stanford and the Chan Zuckerberg Biohub have developed methods for multiple parameter single cell analysis.
Methods to analyze single cells are important for evaluating cell-to-cell variability in biological systems, especially where the characteristics of minority...
Published: 3/17/2023
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Inventor(s): Polly Fordyce, Kara Brower, Alexandera Sockell, Adam White, Yinnian Feng
Keywords(s): Biomolecules, Fluorescence, Microfluidics, RNA-seq, ScRNA-seq, Single Cell, Single Cell Analysis
Category(s): Technology Classifications > Biology
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REAL-TIME OPTICAL BIOSENSORS FOR IN VIVO DETECTION
REAL-TIME OPTICAL BIOSENSORS FOR IN VIVO DETECTION
Researchers at Stanford and the Chan Zuckerberg Biohub have developed a platform for real-time and continuous detection of biomolecules in vivo.
The development of technologies that can monitor circulating biomolecules in vivo, such as continuous glucose monitors, have transformed modern medicine....
Published: 3/17/2023
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Inventor(s): Amani Hariri, Constantin Dory, Alyssa Cartwright, Jelena Vuckovic, Hyongsok Soh
Keywords(s): Aptamer, Biomolecules, Biosensor System, Fluorescence, Molecular Switches, Optical Probe
Category(s): Technology Classifications > Biology, Technology Classifications > Engineering
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