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HYDROGEL PURIFICATION OF CELL MATERIALS FOR PCR-ACTIVATED CELL SORTING
HYDROGEL PURIFICATION OF CELL MATERIALS FOR PCR-ACTIVATED CELL SORTING
Researchers at the NIH and UCSF have developed methods that detect RNA or DNA markers with single molecule sensitivity in cells of interest that allow rapid isolation of these cells or extracts/derivatives of these cells for in-depth transcriptomic, genomic or epigenomic analyses....
Published: 10/26/2023
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Inventor(s): Adam Abate, Iain Clark, Eli Boritz
Keywords(s): High-Throughput, Hydrogel, Microfluidic, Single Cell Genomics, Single Cell Transcriptomics
Category(s): Technology Classifications > Biology
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CAPILLARY-BASED LIQUID-IN-AIR BIOPRINTER
CAPILLARY-BASED LIQUID-IN-AIR BIOPRINTER
Researchers at UCSF have developed an apparatus and methods for dispensing droplets, which can be used to spatially control the placement of cells in many applications including tissue engineering, organoids, stem cell research, and high-throughput screening.
Stage of Research
The inventors have developed...
Published: 9/14/2023
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Inventor(s): Adam Abate, Krzysztof Langer
Keywords(s): Apparatus, Droplet
Category(s): Technology Classifications > Engineering
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SINGLE-CELL CULTURE AND SEQUENCING WITH LIPID-MODIFIED OLIGOS
SINGLE-CELL CULTURE AND SEQUENCING WITH LIPID-MODIFIED OLIGOS
Researchers at UCSF have developed methods for sequencing a single cell from a cell culture sample and obtaining morphologic or phenotypic measurements and information by combining sequencing approaches and spatial hashing (e.g. barcoding) at a single cell level.
There exists a need in...
Published: 7/27/2023
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Inventor(s): Kai-Chun Chang, Adam Abate
Keywords(s): Lipid-Modified, Oligonucleotides, Sequencing, Single Cell
Category(s): Technology Classifications > Biology
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PARTICLE-TEMPLATED EMULSIFICATION IN WELL PLATES
PARTICLE-TEMPLATED EMULSIFICATION IN WELL PLATES
Researchers at UCSF have developed a new method for emulsifying droplet libraries that is highly scalable.
In the past decade, droplet microfluidic technology has revolutionized the sequencing space via single cell RNA-sequencing (scRNA-seq). This technology has vastly increased the resolution of RNA...
Published: 7/6/2023
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Inventor(s): Adam Abate, Daniel Weisgerber
Keywords(s): Digital Droplet PCR, Emulsification, High Throughput Screening, ScRNA-seq
Category(s): Technology Classifications > Biology
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METHODS FOR GENERATING NUCLEIC ACID ENCODED PROTEIN LIBRARIES AND USES THEREOF
METHODS FOR GENERATING NUCLEIC ACID ENCODED PROTEIN LIBRARIES AND USES THEREOF
Researchers at UCSF have developed a new method for generating protein libraries encoded with nucleic acids for more efficient identification of molecular binders.
Basic biological principles dictate that form follows function. As such, protein-protein binding based on...
Published: 7/6/2023
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Inventor(s): Adam Abate, Cyrille Delley
Keywords(s): Binding Partners, Molecular Probe Libraries, Molecular Signature, Protein-Protein Interactions, Single Cell Sequencing
Category(s): Technology Classifications > Biology
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SINGLE-CELL EPIGENOMIC PROFILING USING DROPLET FLUIDICS AND CHEMICALLY MODIFIED HYDROGELS
SINGLE-CELL EPIGENOMIC PROFILING USING DROPLET FLUIDICS AND CHEMICALLY MODIFIED HYDROGELS
Researchers at UCSF have developed materials and methods for high throughput single cell epigenomic sequencing using a capture/profiling approach with hydrogel scaffolds, thus facilitating a scale and form of epigenomic profiling beyond what has been previously...
Published: 7/6/2023
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Inventor(s): Adam Abate, Xiangpeng Li
Keywords(s): DNA Capture, Droplet, Epigenomic, High-Throughput, Hydrogel, Microfluidic, Single-Cell
Category(s): Technology Classifications > Biology
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TESTING DEVICES
TESTING DEVICES
Researchers at UCSF have developed new methods and a device for at home disease testing.
At home testing for SARS-CoV2 using lateral flow technology has been integral to pandemic containment efforts across the globe. Lateral flow diagnostics in general are widely available in point-of-care settings, such as for viral or bacterial...
Published: 7/6/2023
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Inventor(s): Adam Abate, Charles Chiu, Krzysztof Langer, Daniel Weisgerber
Keywords(s): Diagnostics, Infectious Disease, LAMP, Lateral Flow Assay, PCR, Point-of-Care
Category(s): Technology Classifications > Biology
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NUCLEAR DNA-ANTIBODY SEQUENCING FOR JOINT PROFILING OF GENOTYPE AND PROTEIN IN SINGLE NUCLEI
NUCLEAR DNA-ANTIBODY SEQUENCING FOR JOINT PROFILING OF GENOTYPE AND PROTEIN IN SINGLE NUCLEI
Researchers at UCSF have developed a method for joint nucleic acid-protein profiling from single nuclei that can be applied to all manner of biological samples, including frozen tumor specimens or infectious disease samples.
Cellular heterogeneity is an aspect...
Published: 5/18/2023
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Inventor(s): Harish Vasudevan, Benjamin Demaree, Cyrille Delley, Adam Abate
Keywords(s): Antibody, Frozen Specimens, Genotyping, Nuclei, Nucleic Acid, Phenotyping, Protein, Single Cell
Category(s): Technology Classifications > Biology
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MULTIMODE OMICS OF SINGLE TISSUE SAMPLE
MULTIMODE OMICS OF SINGLE TISSUE SAMPLE
Researchers at UCSF have developed a method for multimode OMICs analyses of tissue sections using mass spectrometry imaging, spatial transcriptomics, and genomics on a shared sample.
Currently, mass spec imaging based on MALDI MS is the best way to show the distribution of small chemicals or metabolites of tissues....
Published: 4/20/2023
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Inventor(s): Adam Abate, Linfeng Xu
Keywords(s): Mass Spectrometry, Metabolomics, Spatial Barcoding, Tissue Sample, Tissue Section, Transcriptomics
Category(s): Technology Classifications > Biology
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PARTITIONING CELLS FOR HIGH-THROUGHPUT SINGLE-CELL SEQUENCING
PARTITIONING CELLS FOR HIGH-THROUGHPUT SINGLE-CELL SEQUENCING
Researchers at UCSF have developed a method for high throughput single-cell multi-omic sequencing that is rapid, simple to operate, and offers key innovations over existing technologies.
Single-cell sequencing technologies refer to the methods to obtain genomics, transcriptomics or multi-omics...
Published: 4/20/2023
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Inventor(s): Adam Abate, Xiangpeng Li, Benjamin Demaree
Keywords(s): Genomic DNA, Hydrogel, Microfluidic, Partitioning, Sequencing, Single-Cell, Transcriptomics
Category(s): Technology Classifications > Biology
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