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COMPOSITIONS AND METHODS RELATED TO CORONAVIRUS THERAPIES
COMPOSITIONS AND METHODS RELATED TO CORONAVIRUS THERAPIES
Researchers at Stanford have developed fusion proteins, containing ACE2 domain linked to a fragment of non-neutralizing anti-SARS-CoV-2 spike protein antibody, with a greater breadth of protection than previously described similar fusion proteins.
Coronaviruses are a large family of viruses...
Published: 11/6/2024
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Inventor(s): Peter Kim, Adrian Hugenmatter, Ashley Utz, Matthew Armbrust
Keywords(s): ACE2, Antibody, Coronavirus, Neutralizing, Spike
Category(s): Technology Classifications > Biology
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METHODS AND COMPOSITIONS IN PROGRAMMABLE RECEPTOR FOR ANTIGEN DETECTION AND CUSTOMIZED CELL RESPONSES
METHODS AND COMPOSITIONS IN PROGRAMMABLE RECEPTOR FOR ANTIGEN DETECTION AND CUSTOMIZED CELL RESPONSES
Researchers at Stanford have developed new methods to create programmable synthetic receptors (PAGER).
The advent of programmable synthetic receptors represents a new era in cellular therapies and in biomedical science. There are currently tens...
Published: 12/5/2023
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Inventor(s): Nicholas Kalogriopoulos, Alice Ting, Matthew Ravalin, Reika Tei
Keywords(s): Antibody, Fusion Protein, Receptor
Category(s): Technology Classifications > Biology
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ANTIBODY COMPOSITIONS AND OPTIMIZATION METHODS
ANTIBODY COMPOSITIONS AND OPTIMIZATION METHODS
Researchers at Stanford have invented a method using directed evolution for predicting antibody improved antibody variants.
Evolution searches across an immense space of possible sequences for rare mutations that improve fitness. In nature, this search is based on random mutation and recombination,...
Published: 9/14/2023
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Inventor(s): Brian Hie, Peter Kim
Keywords(s): Antibody, Variant
Category(s): Technology Classifications > Software
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ANTIBODIES TO IL1RN AS MARKERS OF PRETERM BIRTH
ANTIBODIES TO IL1RN AS MARKERS OF PRETERM BIRTH
Researchers at CZ Biohub SF and UCSF have discovered a novel biomarker of pre-term birth.
Little is known about pre-term delivery risk and more specifically the immunological processes that allow for tolerance of a semi-allogenic fetus within the mother’s body. However, the processes that govern...
Published: 8/17/2023
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Inventor(s): Elze Rackaityte, Joseph DeRisi
Keywords(s): Antibody, Biomarker, Preterm Delivery Risk
Category(s): Technology Classifications > Biology
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CORONAVIRUS NEUTRALIZING COMPOSITIONS AND ASSOCIATED METHODS
CORONAVIRUS NEUTRALIZING COMPOSITIONS AND ASSOCIATED METHODS
Researchers at CZ Biohub SF and Stanford have developed unique fusion proteins that have broad therapeutic benefits for the treatment of infection by existing and future coronaviruses.
Coronaviruses cause human illness ranging from the common cold to more severe diseases. They are large,...
Published: 12/5/2024
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Inventor(s): Payton Weidenbacher, Peter Kim, Eric Waltari
Keywords(s): Antibody, Broad-Spectrum, Coronavirus, Fusion Protein, Highly-Conserved, Inhibitor, Neutralizing, Receptor, Variant
Category(s): Technology Classifications > Biology
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NUCLEAR DNA-ANTIBODY SEQUENCING FOR JOINT PROFILING OF GENOTYPE AND PROTEIN IN SINGLE NUCLEI
NUCLEAR DNA-ANTIBODY SEQUENCING FOR JOINT PROFILING OF GENOTYPE AND PROTEIN IN SINGLE NUCLEI
Researchers at UCSF have developed a method for joint nucleic acid-protein profiling from single nuclei that can be applied to all manner of biological samples, including frozen tumor specimens or infectious disease samples.
Cellular heterogeneity is an aspect...
Published: 5/18/2023
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Inventor(s): Harish Vasudevan, Benjamin Demaree, Cyrille Delley, Adam Abate
Keywords(s): Antibody, Frozen Specimens, Genotyping, Nuclei, Nucleic Acid, Phenotyping, Protein, Single Cell
Category(s): Technology Classifications > Biology
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MEASUREMENT OF AFUCOSYLATED IgG Fc GLYCANS TO PREDICT RISK OF SEVERE COVID-19 DISEASE
MEASUREMENT OF AFUCOSYLATED IgG Fc GLYCANS TO PREDICT RISK OF SEVERE COVID-19 DISEASE
Researchers at Stanford have developed a method for identifying a subject that is at risk of progression to clinically significant COVID-19 infection or disease.
A minority of individuals infected with SARS-CoV-2 mount an extreme inflammatory response that...
Published: 3/17/2023
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Inventor(s): Taia Wang
Keywords(s): Afucosylation, Antibody, COVID-19, Glycoform, Glycosylation, IgG, Non-Neutralizing, Receptor, Symptom, Vaccine
Category(s): Technology Classifications > Biology
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METHODS AND COMPOSITIONS FOR SELECTIVE PCR AND CLONING OF ANTIBODY SEQUENCES
METHODS AND COMPOSITIONS FOR SELECTIVE PCR AND CLONING OF ANTIBODY SEQUENCES
Researchers at Stanford University and the CZ Biohub San Francisco have developed a strategy for retrieving and cloning antibody DNA from single cells within a pooled library of cells, enabling the rapid and low-cost cloning and expression of native human antibodies...
Published: 3/17/2023
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Inventor(s): Richard Horns, Stephen Quake
Keywords(s): Antibody, B Cells, cDNA Libraries, DNA Cloning, DNA Libraries, Molecular Cloning, PCR
Category(s): Technology Classifications > Biology
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A TUNABLE PROXIMITY ASSAY THAT CAN OVERCOME DILUTIONAL NON-LINEARITY
A TUNABLE PROXIMITY ASSAY THAT CAN OVERCOME DILUTIONAL NON-LINEARITY
Researchers at Stanford have developed a tunable proximity assay with a wide dynamic range that can detect multiple analytes in a single sample.
Blood-based quantification of protein biomarkers is a standard tool for the prediction, diagnosis, and monitoring of disease. Physiological...
Published: 3/17/2023
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Inventor(s): Hyongsok Soh
Keywords(s): Affinity Reagent, Antibody, Aptamer, Biomolecules, Biosensor System, Blood, Serum
Category(s): Technology Classifications > Biology
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AUTOANTIBODIES AS BIOMARKERS FOR LIPODYSTROPHY
AUTOANTIBODIES AS BIOMARKERS FOR LIPODYSTROPHY
Researchers at UCSF and the Chan Zuckerberg Biohub have developed methods to identify a subject that is at risk of developing autoimmune-related lipodystrophy.
Lipodystrophy is a clinical phenotype defined by a reduction in subcutaneous fat or adipose tissue. Excessive fat loss can lead to an imbalance...
Published: 12/5/2024
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Inventor(s): Caleigh Mandel-Brehm, Joseph DeRisi, Mark Anderson
Keywords(s): Antibody, Autoantibody, Autoimmune, Biomolecules, Diagnosis, IgG, Immunotherapy, Lipodystrophy
Category(s): Technology Classifications > Biology
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