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ENGINEERED ANTIBODY CONSTANT REGION POLYPEPTIDES AND RELATED METHODS
Researchers at Stanford have identified amino acid modifications in the IgG Fc region which extend its therapeutic half-life and improve its in vivo receptor binding.
Biologic therapeutics, including therapeutic antibodies, that incorporate the Fc domain of antibodies are an important and growing class of drugs that have revolutionized the treatment...
Published: 10/23/2025
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Inventor(s): Varun Shanker, Soohyun Kim, Peter Kim
Keywords(s): Antibody, Fc Domain, Therapeutic
Category(s): Technology Classifications > Biology
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COMPOSITIONS AND METHODS RELATED TO CORONAVIRUS THERAPIES
COMPOSITIONS AND METHODS RELATED TO CORONAVIRUS THERAPIES
Researchers at Stanford have developed fusion proteins, containing ACE2 domain linked to a fragment of non-neutralizing anti-SARS-CoV-2 spike protein antibody, with a greater breadth of protection than previously described similar fusion proteins.
Coronaviruses are a large family of viruses...
Published: 11/6/2024
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Inventor(s): Peter Kim, Adrian Hugenmatter, Ashley Utz, Matthew Armbrust
Keywords(s): ACE2, Antibody, Coronavirus, Neutralizing, Spike
Category(s): Technology Classifications > Biology
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DESIGN OF UNIVERSAL H5 INFLUENZA VIRUS VACCINE CANDIDATES VIA ANTIGEN REORIENTATION
DESIGN OF UNIVERSAL H5 INFLUENZA VIRUS VACCINE CANDIDATES VIA ANTIGEN REORIENTATION
Researchers at Stanford University have developed novel universal vaccine candidates for H5 influenza viruses.
Influenza remains a serious threat to public health. H5 avian influenza strains are among the most concerning despite lack of documented human to human...
Published: 9/24/2024
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Inventor(s): Duo Xu, Peter Kim
Keywords(s): Immunofocusing, Vaccine
Category(s): Technology Classifications > Biology
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DESIGN OF A UNIVERSAL INFLUENZA VACCINE CANDIDATES VIA ANTIGEN REORIENTATION
DESIGN OF A UNIVERSAL INFLUENZA VACCINE CANDIDATES VIA ANTIGEN REORIENTATION
Researchers at Stanford have developed a novel universal influenza vaccine candidate.
Vaccines are a major feat of biomedical innovation. Successful vaccines produce broad humoral immunity to a pathogen to prevent subsequent infection. In this vein, adjuvants are compounds...
Published: 12/5/2023
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Inventor(s): Duo Xu, Peter Kim
Keywords(s): Adjuvant, Alum, Infectious Disease, Vaccine
Category(s): Technology Classifications > Biology
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IMMUNOGENIC EBOLAVIRUS FUSION PROTEINS AND RELATED METHODS
IMMUNOGENIC EBOLAVIRUS FUSION PROTEINS AND RELATED METHODS
Researchers at Stanford have developed a novel vaccine strategy for ebolavirus using fusion proteins composed of the virus’ glycoprotein.
Hemorrhagic fevers have become a major public health issue in Africa, the most notable of which being Ebola. Ebola has a notably high mortality...
Published: 10/6/2023
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Inventor(s): Peter Kim, Duo Xu, Abigail Powell
Keywords(s): Ebola Virus, Infectious Disease, Vaccine
Category(s): Technology Classifications > Biology
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ANTIBODY COMPOSITIONS AND OPTIMIZATION METHODS
ANTIBODY COMPOSITIONS AND OPTIMIZATION METHODS
Researchers at Stanford have invented a method using directed evolution for predicting antibody improved antibody variants.
Evolution searches across an immense space of possible sequences for rare mutations that improve fitness. In nature, this search is based on random mutation and recombination,...
Published: 9/14/2023
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Inventor(s): Brian Hie, Peter Kim
Keywords(s): Antibody, Variant
Category(s): Technology Classifications > Software
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CHEMICALLY MODIFIED BACTERIAL PEPTIDOGLYCAN COMPOSITIONS AND USES THEREOF
CHEMICALLY MODIFIED BACTERIAL PEPTIDOGLYCAN COMPOSITIONS AND USES THEREOF
Researchers at Stanford have developed a new microparticle vaccine scaffold for the development of immunogenic subunit vaccines.
Vaccines are one of the most important biomedical advances of the 20th century. Protein vaccines, often referred to as subunit vaccines, have proved...
Published: 8/17/2023
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Inventor(s): Peter Kim, Carolyn Bertozzi, Frances RodrÃguez-Rivera
Keywords(s): Adjuvant, Bacteria, Peptidoglycan, Vaccine
Category(s): Technology Classifications > Biology
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CORONAVIRUS NEUTRALIZING COMPOSITIONS AND ASSOCIATED METHODS
CORONAVIRUS NEUTRALIZING COMPOSITIONS AND ASSOCIATED METHODS
Researchers at CZ Biohub SF and Stanford have developed unique fusion proteins that have broad therapeutic benefits for the treatment of infection by existing and future coronaviruses.
Coronaviruses cause human illness ranging from the common cold to more severe diseases. They are large,...
Published: 12/5/2024
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Inventor(s): Payton Weidenbacher, Peter Kim, Eric Waltari
Keywords(s): Antibody, Broad-Spectrum, Coronavirus, Fusion Protein, Highly-Conserved, Inhibitor, Neutralizing, Receptor, Variant
Category(s): Technology Classifications > Biology
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A METHOD OF IDENTIFYING SMALL MOLECULE INHIBITORS FOR PD-1
A METHOD OF IDENTIFYING SMALL MOLECULE INHIBITORS FOR PD-1
Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have generated a crystal structure for human PD-1 in complex with one of its ligands, PD-L2, for use in small molecule inhibitor design.
Immune checkpoint inhibition of programmed death 1 (PD-1) and its ligand 1 (PD-L1)...
Published: 12/3/2024
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Inventor(s): Shaogeng Tang, Peter Kim
Keywords(s): Crystal Structure, PD-1, PD-L1, Small Molecule Inhibitor
Category(s): Technology Classifications > Biology, Technology Classifications > Chemistry
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A STRATEGY FOR CREATING VACCINES TO ELICIT ANTIBODIES TARGETING A SPECIFIC EPITOPE
A STRATEGY FOR CREATING VACCINES TO ELICIT ANTIBODIES TARGETING A SPECIFIC EPITOPE
Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have developed PMD (Protect, Modify, Deprotect), an immunofocusing strategy that can be used in vaccine development for the generation of antibodies targeting a specific epitope.
Vaccine development...
Published: 3/17/2023
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Inventor(s): Payton Weidenbacher, Peter Kim
Keywords(s): Antibody, Epitope Shield, Immunofocusing, mAb, Monoclonal Antibody, Vaccine
Category(s): Technology Classifications > Biology
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