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CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF

CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF Researchers at Stanford have developed compounds that act as potent anti-cancer drugs which selectively inhibit CDK19 over CD8 and promise a greater therapeutic index and reduced systemic toxicity. Breast cancer remains the leading cause of cancer-related death among women worldwide. Patient mortality...

Published: 7/6/2023 | Inventor(s): Vincent Alford, Mark Smith, Michael Clarke, Jitendra Gurjar, Angera Kuo

Keywords(s): CDK19, CDK8, Compound, Selective Inhibition, Therapeutic, Treatment, Triple Negative Breast Cancer

Category(s): Technology Classifications > Biology

ENGINEERED ACE2 RECEPTOR TRAPS TO BLOCK SARS-COV-2 INFECTION

ENGINEERED ACE2 RECEPTOR TRAPS TO BLOCK SARS-COV-2 INFECTION Researchers at UCSF and the Chan Zuckerberg Biohub have developed a set of ACE2 variants which potently block SAR-CoV-2 infection in cells. SARS-CoV-2 is the stain of coronavirus that causes COVID-19. This virus is characterized by spike proteins on its surface, which mediate infection...

Published: 3/17/2023 | Inventor(s): James Wells, Tanja Kortemme, Jeff Glasgow, Anum Glasgow, Irene Lui, Xin Zhou

Keywords(s): Affinity Reagent, Biomolecules, Therapeutic, Yeast Particle Display

Category(s): Technology Classifications > Biology