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PERILIPIN-1 SPECIFIC T CELLS FOR SELECTIVE FAT TARGETING
Researchers at UCSF and CZ Biohub SF have described cells expressing a heterologous T-cell receptor, that binds to an adipose-specific protein perilipin 1 peptide complex, thereby enabling selecting targeting of fat cells.
T cell tolerance is enforced in the thymus through the expression of a wide array of self proteins called tissue-specific antigens...
Published: 10/23/2025
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Inventor(s): Mark Anderson, Irina Proekt, Joseph DeRisi
Keywords(s): Autoantibody, Autoimmune, Therapeutic
Category(s): Technology Classifications > Biology
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ENGINEERED ANTIBODY CONSTANT REGION POLYPEPTIDES AND RELATED METHODS
Researchers at Stanford have identified amino acid modifications in the IgG Fc region which extend its therapeutic half-life and improve its in vivo receptor binding.
Biologic therapeutics, including therapeutic antibodies, that incorporate the Fc domain of antibodies are an important and growing class of drugs that have revolutionized the treatment...
Published: 10/23/2025
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Inventor(s): Varun Shanker, Soohyun Kim, Peter Kim
Keywords(s): Antibody, Fc Domain, Therapeutic
Category(s): Technology Classifications > Biology
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OPTIMIZING CANCER CHEMOTHERAPY WITH THE GUT MICROBIOME
Researchers at UCSF have developed a novel innovation in harnessing the gut microbiome to alleviate severe side effects of chemotherapy.
Dose-limiting toxicities remain a significant barrier in the advancement of drug therapies, particularly in oncology. Although decades of pharmacogenomic research have identified specific human genetic variants that...
Published: 10/23/2025
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Inventor(s): Peter Turnbaugh, Chloe Atreya, Kidder Wesley, Kai Trepka
Keywords(s): Cancer, Diagnostics, Therapeutic
Category(s): Technology Classifications > Biology
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ANTIBODY DIRECTED THERAPY TO PREVENT AND TREAT CHRONIC LUNG DISEASE OF INFANCY
Researchers at Stanford and CZ Biohub SF have developed a novel antibody mediated strategy for the treatment of pediatric chronic lung diseases.
Over 10% of infants worldwide are born prematurely, many of whom develop bronchopulmonary dysplasia (BPD), a serious lung disease with many comorbities. In the U.S., around 10,000 infants are diagnosed with...
Published: 10/23/2025
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Inventor(s): David Cornfield, Cristina Alvira, Stephen Quake, Carsten Knutsen
Keywords(s): Antibody, Therapeutic
Category(s): Technology Classifications > Biology
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CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF
CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF
Researchers at Stanford have developed compounds that act as potent anti-cancer drugs which selectively inhibit CDK19 over CD8 and promise a greater therapeutic index and reduced systemic toxicity.
Breast cancer remains the leading cause of cancer-related death among women worldwide. Patient mortality...
Published: 7/6/2023
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Inventor(s): Vincent Alford, Mark Smith, Michael Clarke, Jitendra Gurjar, Angera Kuo
Keywords(s): CDK19, CDK8, Compound, Selective Inhibition, Therapeutic, Treatment, Triple Negative Breast Cancer
Category(s): Technology Classifications > Biology
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ENGINEERED ACE2 RECEPTOR TRAPS TO BLOCK SARS-COV-2 INFECTION
ENGINEERED ACE2 RECEPTOR TRAPS TO BLOCK SARS-COV-2 INFECTION
Researchers at UCSF and the Chan Zuckerberg Biohub have developed a set of ACE2 variants which potently block SAR-CoV-2 infection in cells.
SARS-CoV-2 is the stain of coronavirus that causes COVID-19. This virus is characterized by spike proteins on its surface, which mediate infection...
Published: 3/17/2023
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Inventor(s): James Wells, Tanja Kortemme, Jeff Glasgow, Anum Glasgow, Irene Lui, Xin Zhou
Keywords(s): Affinity Reagent, Biomolecules, Therapeutic, Yeast Particle Display
Category(s): Technology Classifications > Biology
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