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METHOD FOR MASSIVELY PARALLEL SCREENING OF APTAMER SWITCHES
METHOD FOR MASSIVELY PARALLEL SCREENING OF APTAMER SWITCHES
Researchers at Stanford have developed a massively parallel screening strategy to screen for target-responsive molecular switches.
Target-responsive RNA- and DNA-based molecular switches have potential utility in a variety of technological applications. Such biosensors are typically...
Published: 3/17/2023
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Inventor(s): Hyongsok Soh
Keywords(s): Affinity Reagent, Aptamer, Base-Modified Nucleotide, Biomolecules, Biosensor System, Fluorescence, High-Throughput, Integrated Screening System, Molecular Switches, Non-Natural Nucleotide
Category(s): Technology Classifications > Biology
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A TUNABLE PROXIMITY ASSAY THAT CAN OVERCOME DILUTIONAL NON-LINEARITY
A TUNABLE PROXIMITY ASSAY THAT CAN OVERCOME DILUTIONAL NON-LINEARITY
Researchers at Stanford have developed a tunable proximity assay with a wide dynamic range that can detect multiple analytes in a single sample.
Blood-based quantification of protein biomarkers is a standard tool for the prediction, diagnosis, and monitoring of disease. Physiological...
Published: 3/17/2023
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Inventor(s): Hyongsok Soh
Keywords(s): Affinity Reagent, Antibody, Aptamer, Biomolecules, Biosensor System, Blood, Serum
Category(s): Technology Classifications > Biology
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QUANTIFICATION OF CELLULAR PROTEINS USING BARCODED BINDING MOIETIES
QUANTIFICATION OF CELLULAR PROTEINS USING BARCODED BINDING MOIETIES
Researchers at Stanford have developed a method enabling quantification of intracellular protein levels using oligonucleotide-barcoded antibodies.
Multiplexing single cell technologies affords researchers the ability to characterize cell states and identify gene regulatory programs...
Published: 3/17/2023
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Inventor(s): William Greenleaf, Amy Chen
Keywords(s): Affinity Reagent, Antibody, Biomolecules, Integrated Screening System, ScRNA-seq, Single Cell, Single Cell Analysis, Single Cell Genomics, Single Cell RNA Sequencing, Single-cell Transcriptomics
Category(s): Technology Classifications > Biology
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CONTINUOUS REAL-TIME MONITORING OF BIOMOLECULES IN LIVE SUBJECTS
CONTINUOUS REAL-TIME MONITORING OF BIOMOLECULES IN LIVE SUBJECTS
Researchers at Stanford have developed methods for the continuous real-time monitoring of biomolecules in live subjects.
Real-time biosensors that can continuously measure circulating biomolecules in vivo would revolutionize the healthcare system by enabling truly personalized...
Published: 3/17/2023
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Inventor(s): Hyongsok Soh, Mahla Poudineh, Jing Pan
Keywords(s): Affinity Reagent, Antibody, Aptamer, Biomolecules, Biosensor System, Blood, Microfluidics
Category(s): Technology Classifications > Engineering
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ENGINEERED ACE2 RECEPTOR TRAPS TO BLOCK SARS-COV-2 INFECTION
ENGINEERED ACE2 RECEPTOR TRAPS TO BLOCK SARS-COV-2 INFECTION
Researchers at UCSF and the Chan Zuckerberg Biohub have developed a set of ACE2 variants which potently block SAR-CoV-2 infection in cells.
SARS-CoV-2 is the stain of coronavirus that causes COVID-19. This virus is characterized by spike proteins on its surface, which mediate infection...
Published: 3/17/2023
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Inventor(s): James Wells, Tanja Kortemme, Jeff Glasgow, Anum Glasgow, Irene Lui, Xin Zhou
Keywords(s): Affinity Reagent, Biomolecules, Therapeutic, Yeast Particle Display
Category(s): Technology Classifications > Biology
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DETECTION ASSAY FOR SARS-COV-2 VIRUS
DETECTION ASSAY FOR SARS-COV-2 VIRUS
Researchers at UCSF and the Chan Zuckerberg Biohub have developed methods to detect SARS-CoV-2 virus.
Clinical laboratory tests and point-of-care tests are needed for screening and diagnosis of individuals infected with SARS-CoV-2 virus. SARS-CoV-2 infection begins with viral Spike protein binding to the human...
Published: 3/17/2023
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Inventor(s): James Wells, Susanna Elledge, Xin Zhou, Tanja Kortemme, Jeff Glasgow, Anum Glasgow, Irene Lui
Keywords(s): Affinity Reagent, Antibody, Biosensor System, Diagnosis, Fc Domain
Category(s): Technology Classifications > Biology
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INDEPENDENT CONTROL OF THE THERMODYNAMIC AND KINETIC PROPERTIES OF APTAMER SWITCHES
INDEPENDENT CONTROL OF THE THERMODYNAMIC AND KINETIC PROPERTIES OF APTAMER SWITCHES
Researchers at Stanford and the Chan Zuckerberg Biohub have developed methods for independent tuning of aptamer switching binding affinities and kinetics.
Aptamers are useful molecular switches with excellent binding properties that can reversibly change their confirmation...
Published: 3/17/2023
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Inventor(s): Hyongsok Soh, Brandon Wilson, Amani Hariri
Keywords(s): Affinity Reagent, Aptamer, Biosensor System, Molecular Switches
Category(s): Technology Classifications > Biology
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PROGRAMMABLE ANTIBODY-BASED MOLECULAR SWITCHES FOR TARGET ANALYTE DETECTION
PROGRAMMABLE ANTIBODY-BASED MOLECULAR SWITCHES FOR TARGET ANALYTE DETECTION
Researchers at Stanford and the Chan Zuckerberg Biohub have developed antibody-based molecular switches for target analyte detection.
The development of technologies that can monitor circulating biomolecules have transformed modern medicine. Molecular switches, which change...
Published: 3/17/2023
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Inventor(s): Jing Pan, Ian Paul Thompson, Brandon Wilson, Hyongsok Soh
Keywords(s): Affinity Reagent, Antibody, Biosensor System, Fc Domain, Molecular Switches
Category(s): Technology Classifications > Biology
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GENERATION AND SCREENING OF NON-NATURAL APTAMER LIBRARIES
GENERATION AND SCREENING OF NON-NATURAL APTAMER LIBRARIES
Researchers at Stanford, supported in part by the Chan Zuckerberg Biohub, have developed an integrated system for the automated generation, screening, and characterization of base-modified aptamers.
High affinity binding reagents have revolutionized biology and medicine. One class of synthetic...
Published: 3/17/2023
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Inventor(s): Trevor Feagin, Diana Wu, Peter Mage, John Coller, Hyongsok Soh
Keywords(s): Affinity Reagent, Aptamer, Base-Modified Nucleotide, Integrated Screening System, Machine Learning
Category(s): Technology Classifications > Biology, Technology Classifications > Chemistry
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