Search Results - aptamer

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INDEPENDENT CONTROL OF THE THERMODYNAMIC AND KINETIC PROPERTIES OF APTAMER SWITCHES
INDEPENDENT CONTROL OF THE THERMODYNAMIC AND KINETIC PROPERTIES OF APTAMER SWITCHES Researchers at Stanford and the Chan Zuckerberg Biohub have developed methods for independent tuning of aptamer switching binding affinities and kinetics. Aptamers are useful molecular switches with excellent binding properties that can reversibly change their confirmation...
Published: 4/16/2021   |   Inventor(s): Hyongsok Soh, Brandon Wilson, Amani Hariri
Keywords(s): Affinity Reagent, Aptamer, Biosensor System, Molecular Switches
Category(s): Technology Classifications > Biology
REAL-TIME OPTICAL BIOSENSORS FOR IN VIVO DETECTION
REAL-TIME OPTICAL BIOSENSORS FOR IN VIVO DETECTION Researchers at Stanford and the Chan Zuckerberg Biohub have developed a platform for real-time and continuous detection of biomolecules in vivo. The development of technologies that can monitor circulating biomolecules in vivo, such as continuous glucose monitors, have transformed modern medicine....
Published: 12/14/2020   |   Inventor(s): Amani Hariri, Constantin Dory, Alyssa Cartwright, Jelena Vuckovic, Hyongsok Soh
Keywords(s): Aptamer, Biomolecules, Biosensor System, Fluorescence, Molecular Switches, Optical Probe
Category(s): Technology Classifications > Biology, Technology Classifications > Engineering
COMPOSITIONS AND METHODS INVOLVING NON-NATURAL APTAMER LIBRARIES
COMPOSITIONS AND METHODS INVOLVING NON-NATURAL APTAMER LIBRARIES Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have developed Click-PD, a framework for the customizable generation of non-natural, base-modified aptamer libraries with diverse chemical modifications. These libraries are used in a high-throughput particle display...
Published: 11/9/2020   |   Inventor(s): Jia Niu, Chelsea Gordon, Hyongsok Soh
Keywords(s): Aptamer, ConA, Non-Natural Nucleotide, Particle Display
Category(s): Technology Classifications > Biology, Technology Classifications > Chemistry
GENERATION AND SCREENING OF NON-NATURAL APTAMER LIBRARIES
GENERATION AND SCREENING OF NON-NATURAL APTAMER LIBRARIES Researchers at Stanford, supported in part by the Chan Zuckerberg Biohub, have developed an integrated system for the automated generation, screening, and characterization of base-modified aptamers. High affinity binding reagents have revolutionized biology and medicine. One class of synthetic...
Published: 11/9/2020   |   Inventor(s): Trevor Feagin, Diana Wu, Peter Mage, John Coller, Hyongsok Soh
Keywords(s): Affinity Reagent, Aptamer, Base-Modified Nucleotide, Integrated Screening System, Machine Learning
Category(s): Technology Classifications > Biology, Technology Classifications > Chemistry