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METHOD FOR MASSIVELY PARALLEL SCREENING OF APTAMER SWITCHES
METHOD FOR MASSIVELY PARALLEL SCREENING OF APTAMER SWITCHES
Researchers at Stanford have developed a massively parallel screening strategy to screen for target-responsive molecular switches.
Target-responsive RNA- and DNA-based molecular switches have potential utility in a variety of technological applications. Such biosensors are typically...
Published: 3/17/2023
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Inventor(s): Hyongsok Soh
Keywords(s): Affinity Reagent, Aptamer, Base-Modified Nucleotide, Biomolecules, Biosensor System, Fluorescence, High-Throughput, Integrated Screening System, Molecular Switches, Non-Natural Nucleotide
Category(s): Technology Classifications > Biology
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A TUNABLE PROXIMITY ASSAY THAT CAN OVERCOME DILUTIONAL NON-LINEARITY
A TUNABLE PROXIMITY ASSAY THAT CAN OVERCOME DILUTIONAL NON-LINEARITY
Researchers at Stanford have developed a tunable proximity assay with a wide dynamic range that can detect multiple analytes in a single sample.
Blood-based quantification of protein biomarkers is a standard tool for the prediction, diagnosis, and monitoring of disease. Physiological...
Published: 3/17/2023
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Inventor(s): Hyongsok Soh
Keywords(s): Affinity Reagent, Antibody, Aptamer, Biomolecules, Biosensor System, Blood, Serum
Category(s): Technology Classifications > Biology
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CONTINUOUS REAL-TIME MONITORING OF BIOMOLECULES IN LIVE SUBJECTS
CONTINUOUS REAL-TIME MONITORING OF BIOMOLECULES IN LIVE SUBJECTS
Researchers at Stanford have developed methods for the continuous real-time monitoring of biomolecules in live subjects.
Real-time biosensors that can continuously measure circulating biomolecules in vivo would revolutionize the healthcare system by enabling truly personalized...
Published: 3/17/2023
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Inventor(s): Hyongsok Soh, Mahla Poudineh, Jing Pan
Keywords(s): Affinity Reagent, Antibody, Aptamer, Biomolecules, Biosensor System, Blood, Microfluidics
Category(s): Technology Classifications > Engineering
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INDEPENDENT CONTROL OF THE THERMODYNAMIC AND KINETIC PROPERTIES OF APTAMER SWITCHES
INDEPENDENT CONTROL OF THE THERMODYNAMIC AND KINETIC PROPERTIES OF APTAMER SWITCHES
Researchers at Stanford and the Chan Zuckerberg Biohub have developed methods for independent tuning of aptamer switching binding affinities and kinetics.
Aptamers are useful molecular switches with excellent binding properties that can reversibly change their confirmation...
Published: 3/17/2023
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Inventor(s): Hyongsok Soh, Brandon Wilson, Amani Hariri
Keywords(s): Affinity Reagent, Aptamer, Biosensor System, Molecular Switches
Category(s): Technology Classifications > Biology
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REAL-TIME OPTICAL BIOSENSORS FOR IN VIVO DETECTION
REAL-TIME OPTICAL BIOSENSORS FOR IN VIVO DETECTION
Researchers at Stanford and the Chan Zuckerberg Biohub have developed a platform for real-time and continuous detection of biomolecules in vivo.
The development of technologies that can monitor circulating biomolecules in vivo, such as continuous glucose monitors, have transformed modern medicine....
Published: 3/17/2023
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Inventor(s): Amani Hariri, Constantin Dory, Alyssa Cartwright, Jelena Vuckovic, Hyongsok Soh
Keywords(s): Aptamer, Biomolecules, Biosensor System, Fluorescence, Molecular Switches, Optical Probe
Category(s): Technology Classifications > Biology, Technology Classifications > Engineering
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COMPOSITIONS AND METHODS INVOLVING NON-NATURAL APTAMER LIBRARIES
COMPOSITIONS AND METHODS INVOLVING NON-NATURAL APTAMER LIBRARIES
Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have developed Click-PD, a framework for the customizable generation of non-natural, base-modified aptamer libraries with diverse chemical modifications. These libraries are used in a high-throughput particle display...
Published: 3/17/2023
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Inventor(s): Jia Niu, Chelsea Gordon, Hyongsok Soh
Keywords(s): Aptamer, ConA, Non-Natural Nucleotide, Particle Display
Category(s): Technology Classifications > Biology, Technology Classifications > Chemistry
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GENERATION AND SCREENING OF NON-NATURAL APTAMER LIBRARIES
GENERATION AND SCREENING OF NON-NATURAL APTAMER LIBRARIES
Researchers at Stanford, supported in part by the Chan Zuckerberg Biohub, have developed an integrated system for the automated generation, screening, and characterization of base-modified aptamers.
High affinity binding reagents have revolutionized biology and medicine. One class of synthetic...
Published: 3/17/2023
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Inventor(s): Trevor Feagin, Diana Wu, Peter Mage, John Coller, Hyongsok Soh
Keywords(s): Affinity Reagent, Aptamer, Base-Modified Nucleotide, Integrated Screening System, Machine Learning
Category(s): Technology Classifications > Biology, Technology Classifications > Chemistry
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