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METHODS FOR ULTRA-HIGH-THROUGHPUT PROFILING OF NUCLEIC ACID BINDING OR MODIFYING PROTEINS
METHODS FOR ULTRA-HIGH-THROUGHPUT PROFILING OF NUCLEIC ACID BINDING OR MODIFYING PROTEINS
Researchers at Stanford have developed a novel method for the mapping of nucleic acid binding or modifying proteins in a massively multiplexed manner.
Next generation sequencing (NGS) has allowed for sequence-agnostic sequencing and has revolutionized every...
Published: 4/22/2024
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Inventor(s): Polly Fordyce
Keywords(s): High-Throughput, Microfluidics, Protein-DNA Interactions
Category(s): Technology Classifications > Engineering
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DROPLET-ELECTROPHORESIS DEVICES AND RELATED METHODS
DROPLET-ELECTROPHORESIS DEVICES AND RELATED METHODS
Researchers at UC Berkeley have developed a novel method for comprehensively profiling the proteomes of single cells.
Genomics (DNA) and transcriptomics (RNA) sequencing is one of the cornerstones of our modern-day understanding of the genetic blueprint of life. Furthermore, sequencing and...
Published: 4/22/2024
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Inventor(s): Amy Herr, Yang Liu
Keywords(s): Microfluidics, Protein, Single Cell Analysis
Category(s): Technology Classifications > Engineering
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CONTINUOUS REAL-TIME MONITORING OF BIOMOLECULES IN LIVE SUBJECTS
CONTINUOUS REAL-TIME MONITORING OF BIOMOLECULES IN LIVE SUBJECTS
Researchers at Stanford have developed methods for the continuous real-time monitoring of biomolecules in live subjects.
Real-time biosensors that can continuously measure circulating biomolecules in vivo would revolutionize the healthcare system by enabling truly personalized...
Published: 3/17/2023
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Inventor(s): Hyongsok Soh, Mahla Poudineh, Jing Pan
Keywords(s): Affinity Reagent, Antibody, Aptamer, Biomolecules, Biosensor System, Blood, Microfluidics
Category(s): Technology Classifications > Engineering
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POINT-OF-CARE AND IMPROVED DETECTION AND QUANTIFICATION OF BIOMOLECULES
POINT-OF-CARE AND IMPROVED DETECTION AND QUANTIFICATION OF BIOMOLECULES
Researchers at UCSF and the Chan Zuckerberg Biohub have developed a workflow for accurate bulk quantitation of droplet digital PCR, which can be used in point-of-care clinical settings with minimal sample processing.
The quantitation of nucleic acids is important for clinical...
Published: 10/26/2024
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Inventor(s): Adam Abate, Xiangpeng Li
Keywords(s): Biomolecules, Diagnosis, Droplet Digital PCR, Fluorescence, High-Throughput, Microfluidics, SARS-CoV-2
Category(s): Technology Classifications > Biology
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MICROFLUIDIC CELL BARCODING AND SEQUENCING
MICROFLUIDIC CELL BARCODING AND SEQUENCING
Researchers at UC Berkeley have developed µCB-seq, a microfluidic cell barcoding and sequencing platform for high-resolution imaging and sequencing of single cells.
Single-cell RNA sequencing (scRNA-seq) enables the investigation of complex biological processes in multicellular organisms with high...
Published: 3/17/2023
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Inventor(s): Aaron Streets, Tyler Chen, Anushka Gupta
Keywords(s): Fluorescence, Genetic Dissection, Microfluidics, ScRNA-seq, Single Cell, Single Cell Analysis, Single Cell Genomics, Single Cell RNA Sequencing, Single-cell Transcriptomics
Category(s): Technology Classifications > Biology
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IMAGING AND SEQUENCING PROTEIN-DNA INTERACTIONS IN SINGLE CELLS USING INTEGRATED MICROFLUIDICS
IMAGING AND SEQUENCING PROTEIN-DNA INTERACTIONS IN SINGLE CELLS USING INTEGRATED MICROFLUIDICS
Researchers at UC Berkeley have developed an integrated microfluidics method, µDamID (microfluidic DamID), capable of co-determining the cellular location and nucleotide sequence of DNA that is contacted by a protein of interest in a single cell.
Genome...
Published: 3/17/2023
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Inventor(s): Aaron Streets, Nicolas Altemose
Keywords(s): Fluorescence, Genetic Dissection, Microfluidics, Optical Probe, Single Cell, Single Cell Analysis
Category(s): Technology Classifications > Biology
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SCITO-SEQ: SINGLE CELL COMBINATORIAL INDEXED CYTOMETRY SEQUENCING
SCITO-SEQ: SINGLE CELL COMBINATORIAL INDEXED CYTOMETRY SEQUENCING
Researchers at UCSF have developed SCITO-seq, a new workflow for single cell sequencing-based proteomics.
The use of DNA to barcode and tag antibodies has created new opportunities to use sequencing to profile the molecular properties of thousands of cells simultaneously. Furthermore,...
Published: 1/19/2024
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Inventor(s): Chun Ye, Byungjin Hwang, David Lee
Keywords(s): Antibody, Droplet-Based Single Cell Sequencing, dsc-Seq, Microfluidics, Proteomics, Single Cell, Single Cell Analysis
Category(s): Technology Classifications > Biology
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MULTIPLEXED DETECTION AND CHARACTERIZATION OF MICROBIAL NUCLEIC ACIDS USING SPECTRALLY ENCODED BEADS
MULTIPLEXED DETECTION AND CHARACTERIZATION OF MICROBIAL NUCLEIC ACIDS USING SPECTRALLY ENCODED BEADS
Researchers at Stanford and the Chan Zuckerberg Biohub have developed a platform for characterizing a population of microbes using spectrally encoded beads.
The clinical treatment of microbial infections is dependent on the proper identification and...
Published: 3/17/2023
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Inventor(s): Adam White, Huy Nguyen, Feiqiao Yu, Tyler Shimko, Polly Fordyce, Nadya Andini, Samuel Yang
Keywords(s): Blood, Diagnosis, Fluorescence, Microbe, Microfluidics, Nucleic Acid, RNA-seq
Category(s): Technology Classifications > Biology
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MULTI-PARAMETRIC SINGLE CELL ANALYSIS USING SPECTRALLY ENCODED MICROBEADS
MULTI-PARAMETRIC SINGLE CELL ANALYSIS USING SPECTRALLY ENCODED MICROBEADS
Researchers at Stanford and the Chan Zuckerberg Biohub have developed methods for multiple parameter single cell analysis.
Methods to analyze single cells are important for evaluating cell-to-cell variability in biological systems, especially where the characteristics of minority...
Published: 3/17/2023
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Inventor(s): Polly Fordyce, Kara Brower, Alexandera Sockell, Adam White, Yinnian Feng
Keywords(s): Biomolecules, Fluorescence, Microfluidics, RNA-seq, ScRNA-seq, Single Cell, Single Cell Analysis
Category(s): Technology Classifications > Biology
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MULTI-PARAMETRIC AND HIGH-THROUGHPUT SINGLE CELL ANALYSIS
MULTI-PARAMETRIC AND HIGH-THROUGHPUT SINGLE CELL ANALYSIS
Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have generated a method for performing multi-parametric and high-throughput single cell genomic and phenotypic analyses.
Single cell -omics, the study of diverse biological processes such as genome, RNA or protein expression...
Published: 3/17/2023
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Inventor(s): Polly Fordyce, Kara Brower, Sandy Klemm, William Greenleaf
Keywords(s): High-Throughput, Microfluidics, Single Cell, Single Cell Analysis, Single Cell Genomics
Category(s): Technology Classifications > Biology
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