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METHODS FOR ULTRA-HIGH-THROUGHPUT PROFILING OF NUCLEIC ACID BINDING OR MODIFYING PROTEINS
METHODS FOR ULTRA-HIGH-THROUGHPUT PROFILING OF NUCLEIC ACID BINDING OR MODIFYING PROTEINS
Researchers at Stanford have developed a novel method for the mapping of nucleic acid binding or modifying proteins in a massively multiplexed manner.
Next generation sequencing (NGS) has allowed for sequence-agnostic sequencing and has revolutionized every...
Published: 4/22/2024
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Inventor(s): Polly Fordyce
Keywords(s): High-Throughput, Microfluidics, Protein-DNA Interactions
Category(s): Technology Classifications > Engineering
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KINASE/PHOSPHATASTE SUBSTRATE ANALYSIS AND COMPOSITIONS USING SPECTRALLY ENCODED MICROBEADS
KINASE/PHOSPHATASTE SUBSTRATE ANALYSIS AND COMPOSITIONS USING SPECTRALLY ENCODED MICROBEADS
Researchers at Stanford have developed a multiplexed bead-based dephosphorylation assay to allow for the measurement of multiple dephosphorylation reactions in one experiment.
Post-translational modification involves the modification of proteins after...
Published: 9/14/2023
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Inventor(s): Polly Fordyce, Jamin Hein
Keywords(s): Lanthanide, Multiplex, Spectrally Encoded Beads
Category(s): Technology Classifications > Biology
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MICROBEADS WITH RADIOMETRIC LANTHANIDE ENCODING FOR DRUG SCREENING
MICROBEADS WITH RADIOMETRIC LANTHANIDE ENCODING FOR DRUG SCREENING
Researchers at Stanford have developed a new method of drug screening using lanthanide-encoded beads.
Protein-protein interactions are one of the most fundamental biological processes which biomedical science has sought to engineer. Many currently available medications selectively...
Published: 12/19/2023
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Inventor(s): Polly Fordyce, Jamin Hein
Keywords(s): High Throughput Screening, Lanthanide, Multiplex, Spectrally Encoded Beads
Category(s): Technology Classifications > Biology
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ARRAY PLATFORM FOR HIGH-THROUGHPUT ORGANOID PROFILING
ARRAY PLATFORM FOR HIGH-THROUGHPUT ORGANOID PROFILING
Researchers at Stanford have developed a new methodology for image processing that allows for high-throughput characterization of organoid phenotypes.
Organoids represent a major step forward in in vitro research studies into a myriad of disease states. 3D organoid models possess key advantages...
Published: 9/14/2023
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Inventor(s): Polly Fordyce, Christina Curtis, Alexandera Sockell, Wing Wong
Keywords(s): CRISPR, High-Throughput, Imaging, Organoid
Category(s): Technology Classifications > Biology
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METHODS AND COMPOSITIONS RELATED TO LANTHANIDE-ENCODED MICROBEADS
METHODS AND COMPOSITIONS RELATED TO LANTHANIDE-ENCODED MICROBEADS
Researchers at Stanford University have developed a bespoke method for multiplexing beads in bioassays that expands the possible coding space when compared to available bead barcoding technologies.
Multiplexed bioassays have drastically improved our understanding of complex biological...
Published: 3/17/2023
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Inventor(s): Yinnian Feng, Adam White, Jamin Hein, Polly Fordyce
Keywords(s): Barcoded Beads, Bioassay, Bioconjugation, Lanthanide, Microbeads, Multiplexed
Category(s): Technology Classifications > Chemistry
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HIGH-THROUGHPUT FORCE-DEPENDENT CELLULAR RESPONSE ASSAY USING SPECTRALLY ENCODED SMART BEADS
HIGH-THROUGHPUT FORCE-DEPENDENT CELLULAR RESPONSE ASSAY USING SPECTRALLY ENCODED SMART BEADS
Researchers at Stanford have developed a technology that uses biomechanical force to initiate T-cell triggering in a high throughput method, facilitating the exploration of the force- and sequence-dependent landscape of T-cell responses.
Adaptive immunity...
Published: 3/17/2023
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Inventor(s): Xiang Zhao, Adam White, Polly Fordyce, Yinnian Feng, K Garcia
Keywords(s): Catch Bond, High-Throughput Mechanobiology, Ligand Discrimination, Mechanotransduction, Single-Cell Microfluidics, Spectrally Encoded Beads, T-Cell Activation, T-Cell Biophysics, T-Cell Receptor
Category(s): Technology Classifications > Biology
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MULTIPLEXED DETECTION AND CHARACTERIZATION OF MICROBIAL NUCLEIC ACIDS USING SPECTRALLY ENCODED BEADS
MULTIPLEXED DETECTION AND CHARACTERIZATION OF MICROBIAL NUCLEIC ACIDS USING SPECTRALLY ENCODED BEADS
Researchers at Stanford and the Chan Zuckerberg Biohub have developed a platform for characterizing a population of microbes using spectrally encoded beads.
The clinical treatment of microbial infections is dependent on the proper identification and...
Published: 3/17/2023
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Inventor(s): Adam White, Huy Nguyen, Feiqiao Yu, Tyler Shimko, Polly Fordyce, Nadya Andini, Samuel Yang
Keywords(s): Blood, Diagnosis, Fluorescence, Microbe, Microfluidics, Nucleic Acid, RNA-seq
Category(s): Technology Classifications > Biology
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MULTI-PARAMETRIC SINGLE CELL ANALYSIS USING SPECTRALLY ENCODED MICROBEADS
MULTI-PARAMETRIC SINGLE CELL ANALYSIS USING SPECTRALLY ENCODED MICROBEADS
Researchers at Stanford and the Chan Zuckerberg Biohub have developed methods for multiple parameter single cell analysis.
Methods to analyze single cells are important for evaluating cell-to-cell variability in biological systems, especially where the characteristics of minority...
Published: 3/17/2023
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Inventor(s): Polly Fordyce, Kara Brower, Alexandera Sockell, Adam White, Yinnian Feng
Keywords(s): Biomolecules, Fluorescence, Microfluidics, RNA-seq, ScRNA-seq, Single Cell, Single Cell Analysis
Category(s): Technology Classifications > Biology
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MULTI-PARAMETRIC AND HIGH-THROUGHPUT SINGLE CELL ANALYSIS
MULTI-PARAMETRIC AND HIGH-THROUGHPUT SINGLE CELL ANALYSIS
Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have generated a method for performing multi-parametric and high-throughput single cell genomic and phenotypic analyses.
Single cell -omics, the study of diverse biological processes such as genome, RNA or protein expression...
Published: 3/17/2023
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Inventor(s): Polly Fordyce, Kara Brower, Sandy Klemm, William Greenleaf
Keywords(s): High-Throughput, Microfluidics, Single Cell, Single Cell Analysis, Single Cell Genomics
Category(s): Technology Classifications > Biology
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