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INTEGRATED HOST-MICROBE METAGENOMICS OF CELL-FREE NUCLEIC ACID FOR SEPSIS DIAGNOSIS
INTEGRATED HOST-MICROBE METAGENOMICS OF CELL-FREE NUCLEIC ACID FOR SEPSIS DIAGNOSIS
Researchers at UCSF and the Chan Zuckerberg Institute have developed a single-sample metagenomic approach combining host transcriptional profiling with unbiased pathogen detection to improve sepsis diagnosis.
Sepsis causes 20% of all deaths globally and contributes...
Published: 9/14/2023
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Inventor(s): Charles (Chaz) Langelier, Katrina Kalantar, Lucile Neyton, Carolyn Calfee
Keywords(s): Cell-Free DNA, cfDNA, Diagnosis, Next Generation Sequencing (NGS), Sepsis
Category(s): Technology Classifications > Biology
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AUTOANTIBODIES AS BIOMARKERS FOR LIPODYSTROPHY
AUTOANTIBODIES AS BIOMARKERS FOR LIPODYSTROPHY
Researchers at UCSF and the Chan Zuckerberg Biohub have developed methods to identify a subject that is at risk of developing autoimmune-related lipodystrophy.
Lipodystrophy is a clinical phenotype defined by a reduction in subcutaneous fat or adipose tissue. Excessive fat loss can lead to an imbalance...
Published: 3/17/2023
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Inventor(s): Caleigh Mandel-Brehm, Joseph DeRisi, Mark Anderson
Keywords(s): Antibody, Autoantibody, Autoimmune, Biomolecules, Diagnosis, IgG, Immunotherapy, Lipodystrophy
Category(s): Technology Classifications > Biology
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NUCLEIC ACID SEQUENCE DETECTION BY MEASURING FREE MONORIBONUCLEOTIDES GENERATED BY ENDONUCLEASE COLLATERAL CLEAVAGE ACTIVITY
NUCLEIC ACID SEQUENCE DETECTION BY MEASURING FREE MONORIBONUCLEOTIDES GENERATED BY ENDONUCLEASE COLLATERAL CLEAVAGE ACTIVITY
Researchers at the Chan Zuckerberg Biohub have developed an improved method to detect target nucleic acid sequences in a biological sample, NANCI™.
CRISPR-associated protein (Cas) technology is a sequence-specific...
Published: 3/17/2023
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Inventor(s): Emily Crawford, Amy Lyden
Keywords(s): Biomolecules, Biosensor System, CRISPR, Diagnosis, Nuclease
Category(s): Technology Classifications > Biology
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METHODS FOR PREDICTING THE RESPONSE TO METHOTREXATE AND TREATING RHEUMATOID ARTHRITIS
METHODS FOR PREDICTING THE RESPONSE TO METHOTREXATE AND TREATING RHEUMATOID ARTHRITIS
Researchers at UCSF have developed methods of treating Rheumatoid arthritis and for predicting the response of patients to methotrexate.
Rheumatoid arthritis (RA) is an autoimmune disease that leads to inflammation and destruction of joints, as well as other...
Published: 3/17/2023
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Inventor(s): Renuka Nayak, Peter Turnbaugh
Keywords(s): Diagnosis, Immunotherapy
Category(s): Technology Classifications > Biology
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AUTOANTIBODIES AS BIOMARKERS FOR AUTOIMMUNE POLYGLANDULAR SYNDROME TYPE 1
AUTOANTIBODIES AS BIOMARKERS FOR AUTOIMMUNE POLYGLANDULAR SYNDROME TYPE 1
Researchers at UCSF and the Chan Zuckerberg Biohub have identified multiple common autoantibody targets in APS1 patients through proteome-wide programmable phage-display.
The identification of autoantigens remains a critical challenge for understanding and treating autoimmune...
Published: 3/17/2023
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Inventor(s): Sara Vazquez, Mark Anderson, Joseph DeRisi
Keywords(s): Antibody, Autoantibody, Diagnosis, Particle Display, Serum
Category(s): Technology Classifications > Biology
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POINT-OF-CARE AND IMPROVED DETECTION AND QUANTIFICATION OF BIOMOLECULES
POINT-OF-CARE AND IMPROVED DETECTION AND QUANTIFICATION OF BIOMOLECULES
Researchers at UCSF and the Chan Zuckerberg Biohub have developed a workflow for accurate bulk quantitation of droplet digital PCR, which can be used in point-of-care clinical settings with minimal sample processing.
The quantitation of nucleic acids is important for clinical...
Published: 3/17/2023
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Inventor(s): Adam Abate, Xiangpeng Li
Keywords(s): Biomolecules, Diagnosis, Droplet Digital PCR, Fluorescence, High-Throughput, Microfluidics, SARS-CoV-2
Category(s): Technology Classifications > Biology
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METHODS, COMPOSITIONS, AND KITS FOR ASSESSING ENDOMETRIAL TRANSFORMATION
METHODS, COMPOSITIONS, AND KITS FOR ASSESSING ENDOMETRIAL TRANSFORMATION
Researchers at Stanford and the Chan Zuckerberg Biohub have developed a transcriptomic characterization of human endometrium and identified specific gene signatures for use in evaluating endometrial samples for one or more menstrual cycle events.
In a human menstrual cycle,...
Published: 11/29/2023
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Inventor(s): Stephen Quake, Carlos Simon, Wanxin Wang, Felipe Viella
Keywords(s): Diagnosis, Single Cell, Single Cell RNA Sequencing, Single-cell Transcriptomics
Category(s): Technology Classifications > Biology
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PREDICTION OF PREECLAMPSIA RISK USING CIRCULATING CELL-FREE RNA
PREDICTION OF PREECLAMPSIA RISK USING CIRCULATING CELL-FREE RNA
Researchers at Stanford and the Chan Zuckerberg Biohub have developed methods for predicting the risk or existence of preeclampsia.
Preeclampsia, a multi-organ syndrome diagnosed after 20 weeks of gestation, is associated with an increase in adverse maternal and perinatal outcomes. Detection...
Published: 3/17/2023
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Inventor(s): Stephen Quake, Gary Shaw, David Stevenson, Mira Moufarrej
Keywords(s): cfRNA, Diagnosis, Gestational Age, Machine Learning, Maternal Blood, Maternal Plasma
Category(s): Technology Classifications > Biology
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BIOSENSOR DETECTION ASSAY FOR ANTI-SARS-COV-2 ANTIBODIES
BIOSENSOR DETECTION ASSAY FOR ANTI-SARS-COV-2 ANTIBODIES
Researchers at UCSF and the Chan Zuckerberg Biohub have developed a serological detection assay for anti-SARS-CoV-2 antibodies.
COVID-19, caused by the SARS-CoV-2 virus, has spread throughout the world. Early detection of disease using viral detection assays is critical for containing the spread...
Published: 3/17/2023
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Inventor(s): James Wells, Susanna Elledge, Xin Zhou
Keywords(s): Antibody, Biosensor System, Diagnosis, Epitope Shield, IgG
Category(s): Technology Classifications > Biology
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DETECTION ASSAY FOR SARS-COV-2 VIRUS
DETECTION ASSAY FOR SARS-COV-2 VIRUS
Researchers at UCSF and the Chan Zuckerberg Biohub have developed methods to detect SARS-CoV-2 virus.
Clinical laboratory tests and point-of-care tests are needed for screening and diagnosis of individuals infected with SARS-CoV-2 virus. SARS-CoV-2 infection begins with viral Spike protein binding to the human...
Published: 3/17/2023
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Inventor(s): James Wells, Susanna Elledge, Xin Zhou, Tanja Kortemme, Jeff Glasgow, Anum Glasgow, Irene Lui
Keywords(s): Affinity Reagent, Antibody, Biosensor System, Diagnosis, Fc Domain
Category(s): Technology Classifications > Biology
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