Search Results - crispr

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ENGINEERED MULTI-SEGMENTED RNA VIRUSES FOR LARGE-SCALE COMBINATORIAL GENETIC SCREENING
­ENGINEERED MULTI-SEGMENTED RNA VIRUSES FOR LARGE-SCALE COMBINATORIAL GENETIC SCREENING Researchers at UCSF and the Chan Zuckerberg Biohub have engineered multi-segmented RNA viruses for use in generating large-scale combinatorial libraries. Targeted genetic screening, for example using CRISPR-based systems, is useful to dissect biological pathways....
Published: 5/19/2022   |   Inventor(s): Joseph DeRisi, Hanna Retallack
Keywords(s): Cas9, CRISPR, CRISPRi, Integrated Screening System, Nuclease
Category(s): Technology Classifications > Biology
­NUCLEIC ACID SEQUENCE DETECTION BY MEASURING FREE MONORIBONUCLEOTIDES GENERATED BY ENDONUCLEASE COLLATERAL CLEAVAGE ACTIVITY
­NUCLEIC ACID SEQUENCE DETECTION BY MEASURING FREE MONORIBONUCLEOTIDES GENERATED BY ENDONUCLEASE COLLATERAL CLEAVAGE ACTIVITY Researchers at the Chan Zuckerberg Biohub have developed an improved method to detect target nucleic acid sequences in a biological sample, NANCI™. CRISPR-associated protein (Cas) technology is a sequence-specific...
Published: 5/19/2022   |   Inventor(s): Emily Crawford, Amy Lyden
Keywords(s): Biomolecules, Biosensor System, CRISPR, Diagnosis, Nuclease
Category(s): Technology Classifications > Biology
­PHAGE-MEDIATED DELIVERY OF GENES TO GUT MICROBIOME
­PHAGE-MEDIATED DELIVERY OF GENES TO GUT MICROBIOME Researchers at UCSF have developed methods to engineer bacteriophage for gene delivery to gut microbiome. There is broad interest in the influence that the gut microbiome has on host health and disease. Mechanistic insights into the role of the human gut microbiome in the predisposition to and...
Published: 1/14/2022   |   Inventor(s): Kathy Lam, Peter Spanogiannopoulos, Peter Turnbaugh
Keywords(s): Bacterial Pathogenesis, CRISPR, Genome Editing
Category(s): Technology Classifications > Biology
FLASH-MS: FINDING LOW ABUNDANCE SEQUENCES BY CAS9 HYBRIDIZATION MASS SPECTROMETRY
FLASH-MS: FINDING LOW ABUNDANCE SEQUENCES BY CAS9 HYBRIDIZATION MASS SPECTROMETRY Researchers at the Chan Zuckerberg Biohub have developed FLASH-MS, a method for nucleic acid sequence detection by endonuclease digestion and mass spectrometry. The rapid detection of low abundance targets from clinical specimens is a central challenge in clinical diagnostics....
Published: 8/12/2021   |   Inventor(s): Emily Crawford
Keywords(s): Cas9, CRISPR, Genome Dissection, Nuclease, RNA Sequencing
Category(s): Technology Classifications > Biology
BARCODED CLONAL TRACKING OF GENE TARGETING IN CELLS
BARCODED CLONAL TRACKING OF GENE TARGETING IN CELLS Researchers at Stanford and the Chan Zuckerberg Biohub have developed a methodology to monitor cell expansion and differentiation following targeted genomic modification. Targeted DNA correction of disease-causing mutations offers promise in the treatment of genetic diseases. Following targeted...
Published: 2/11/2021   |   Inventor(s): Danny Dever, Rajiv Sharma, Matthew Porteus, Ravindra Majeti, Joab Camarena, Thomas Koehnke
Keywords(s): Blood, Cas9, CRISPR, Genome Editing, Genome Integration, Nuclease
Category(s): Technology Classifications > Biology
FLASH (FINDING LOW ABUNDANCE SEQUENCES BY HYBRIDIZATION)
FLASH (FINDING LOW ABUNDANCE SEQUENCES BY HYBRIDIZATION) Researchers at the Chan Zuckerberg Biohub have developed an improved technique, FLASH, which uses a programmable nuclease to enrich target sequences during preparation of nucleotide libraries. Next generation sequencing (NGS) technology is a powerful tool in diagnostic and functional genomics....
Published: 12/16/2020   |   Inventor(s): Emily Crawford, Jenai Quan
Keywords(s): Cas9, CRISPR, Multiplex PCR, Next Generation Sequencing (NGS), Nucleic Acid Library
Category(s): Technology Classifications > Biology
DISCOVERY OF A HIGHLY THERMOSTABLE CAS9 VARIANT
DISCOVERY OF A HIGHLY THERMOSTABLE CAS9 VARIANT Researchers at Stanford and the Chan Zuckerberg Biohub have discovered a Cas9 protein variant from Ignavibacterium that is thermostable at elevated temperatures. The application of genome editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated...
Published: 11/9/2020   |   Inventor(s): Stephen Quake, Stephanie Schmidt, Feiqiao Yu, Paul Blainey, Andrew May
Keywords(s): Cas9, CRISPR, Genome Editing, Nuclease, Themostable
Category(s): Technology Classifications > Biology