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FLASH-MS: FINDING LOW ABUNDANCE SEQUENCES BY CAS9 HYBRIDIZATION MASS SPECTROMETRY
FLASH-MS: FINDING LOW ABUNDANCE SEQUENCES BY CAS9 HYBRIDIZATION MASS SPECTROMETRY
Researchers at the Chan Zuckerberg Biohub have developed FLASH-MS, a method for nucleic acid sequence detection by endonuclease digestion and mass spectrometry.
The rapid detection of low abundance targets from clinical specimens is a central challenge in clinical diagnostics....
Published: 3/17/2023
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Inventor(s): Emily Crawford
Keywords(s): Cas9, CRISPR, Genome Dissection, Nuclease, RNA Sequencing
Category(s): Technology Classifications > Biology
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BARCODED CLONAL TRACKING OF GENE TARGETING IN CELLS
BARCODED CLONAL TRACKING OF GENE TARGETING IN CELLS
Researchers at Stanford and the Chan Zuckerberg Biohub have developed a methodology to monitor cell expansion and differentiation following targeted genomic modification.
Targeted DNA correction of disease-causing mutations offers promise in the treatment of genetic diseases. Following targeted...
Published: 3/17/2023
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Inventor(s): Daniel Dever, Rajiv Sharma, Matthew Porteus, Ravindra Majeti, Joab Camarena, Thomas Koehnke
Keywords(s): Blood, Cas9, CRISPR, Genome Editing, Genome Integration, Nuclease
Category(s): Technology Classifications > Biology
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FLASH (FINDING LOW ABUNDANCE SEQUENCES BY HYBRIDIZATION)
FLASH (FINDING LOW ABUNDANCE SEQUENCES BY HYBRIDIZATION)
Researchers at the Chan Zuckerberg Biohub have developed an improved technique, FLASH, which uses a programmable nuclease to enrich target sequences during preparation of nucleotide libraries.
Next generation sequencing (NGS) technology is a powerful tool in diagnostic and functional genomics....
Published: 3/17/2023
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Inventor(s): Emily Crawford, Jenai Quan
Keywords(s): Cas9, CRISPR, Multiplex PCR, Next Generation Sequencing (NGS), Nucleic Acid Library
Category(s): Technology Classifications > Biology
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DISCOVERY OF A HIGHLY THERMOSTABLE CAS9 VARIANT
DISCOVERY OF A HIGHLY THERMOSTABLE CAS9 VARIANT
Researchers at Stanford and the Chan Zuckerberg Biohub have discovered a Cas9 protein variant from Ignavibacterium that is thermostable at elevated temperatures.
The application of genome editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated...
Published: 3/17/2023
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Inventor(s): Stephen Quake, Stephanie Schmidt, Feiqiao Yu, Paul Blainey, Andrew May
Keywords(s): Cas9, CRISPR, Genome Editing, Nuclease, Themostable
Category(s): Technology Classifications > Biology
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