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NON-INVASIVE PROFILING OF URINARY TRACT TISSUES WITH URINE LIQUID BIOPSY
NON-INVASIVE PROFILING OF URINARY TRACT TISSUES WITH URINE LIQUID BIOPSY
Researchers at Stanford and UCSFhave determined methods of performing cell-free RNA (cfRNA) transcriptomics and metabolomics on urine samples.
Urine is assayed alongside blood in medicine, however current clinical diagnostic tests exploit only a minor fraction of its biomolecular...
Published: 2/14/2024
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Inventor(s): Sevahn Vorperian, Stephen Quake, Gabriel Loeb
Keywords(s): Biopsy, cfRNA, Liquid, Urine
Category(s): Technology Classifications > Biology
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PROFILING CELL TYPES IN CIRCULATING NUCLEIC ACID LIQUID BIOPSY
PROFILING CELL TYPES IN CIRCULATING NUCLEIC ACID LIQUID BIOPSY
Researchers at Stanford have developed a method to identify cell types of origin for cell-free RNA from liquid biopsies for a variety of diseases.
Cell-free RNA (cfRNA) in blood plasma samples enables dynamic and longitudinal phenotyping for physiological conditions spanning oncology,...
Published: 7/6/2023
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Inventor(s): Sevahn Vorperian, Stephen Quake, Mira Moufarrej
Keywords(s): Biopsy, Cell Free RNA, Cell Pathophysiology, Cell-Of-Origin Identity, Disease, Liquid
Category(s): Technology Classifications > Biology
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DISEASE MANAGEMENT SYSTEM
DISEASE MANAGEMENT SYSTEM
Researchers at CZ Biohub SF and Stanford University have developed a new disease management system that enables efficient population-level tracking of disease incidence rates.
In recent years, the risk of pandemics has become much more visible to the public. As a result of ongoing international development and our ever-growing...
Published: 11/8/2023
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Inventor(s): Patrick Arensdorf, Stephen Quake
Keywords(s): Cloud Platform, Infectious Diseases, Low Cost, Population-Level Tracking, Public Health, Self-Collection, Testing Platform
Category(s): Technology Classifications > Software
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TOTAL RNA PROFILING OF BIOLOGICAL SAMPLES AND SINGLE CELLS
TOTAL RNA PROFILING OF BIOLOGICAL SAMPLES AND SINGLE CELLS
Researchers at Stanford and CZ Biohub San Francisco have developed a method capable of assaying a broad spectrum of coding and noncoding RNA from a single cell, thus enabling simultaneous analysis of protein-coding, long-noncoding, microRNA and other noncoding RNA transcripts from single...
Published: 3/17/2023
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Inventor(s): Alina Isakova, Norma Neff, Stephen Quake
Keywords(s): Noncoding RNA, Single Cell RNA Sequencing
Category(s): Technology Classifications > Biology
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METHODS AND COMPOSITIONS FOR SELECTIVE PCR AND CLONING OF ANTIBODY SEQUENCES
METHODS AND COMPOSITIONS FOR SELECTIVE PCR AND CLONING OF ANTIBODY SEQUENCES
Researchers at Stanford University and the CZ Biohub San Francisco have developed a strategy for retrieving and cloning antibody DNA from single cells within a pooled library of cells, enabling the rapid and low-cost cloning and expression of native human antibodies...
Published: 3/17/2023
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Inventor(s): Richard Horns, Stephen Quake
Keywords(s): Antibody, B Cells, cDNA Libraries, DNA Cloning, DNA Libraries, Molecular Cloning, PCR
Category(s): Technology Classifications > Biology
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METHODS, COMPOSITIONS, AND KITS FOR ASSESSING ENDOMETRIAL TRANSFORMATION
METHODS, COMPOSITIONS, AND KITS FOR ASSESSING ENDOMETRIAL TRANSFORMATION
Researchers at Stanford and the Chan Zuckerberg Biohub have developed a transcriptomic characterization of human endometrium and identified specific gene signatures for use in evaluating endometrial samples for one or more menstrual cycle events.
In a human menstrual cycle,...
Published: 11/29/2023
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Inventor(s): Stephen Quake, Carlos Simon, Wanxin Wang, Felipe Viella
Keywords(s): Diagnosis, Single Cell, Single Cell RNA Sequencing, Single-cell Transcriptomics
Category(s): Technology Classifications > Biology
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PREDICTION OF PREECLAMPSIA RISK USING CIRCULATING CELL-FREE RNA
PREDICTION OF PREECLAMPSIA RISK USING CIRCULATING CELL-FREE RNA
Researchers at Stanford and the Chan Zuckerberg Biohub have developed methods for predicting the risk or existence of preeclampsia.
Preeclampsia, a multi-organ syndrome diagnosed after 20 weeks of gestation, is associated with an increase in adverse maternal and perinatal outcomes. Detection...
Published: 10/14/2024
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Inventor(s): Stephen Quake, Gary Shaw, David Stevenson, Mira Moufarrej
Keywords(s): cfRNA, Diagnosis, Gestational Age, Machine Learning, Maternal Blood, Maternal Plasma
Category(s): Technology Classifications > Biology
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BROADLY NEUTRALIZING ANTIBODIES AGAINST DENGUE VIRUS
BROADLY NEUTRALIZING ANTIBODIES AGAINST DENGUE VIRUS
Researchers at Stanford and the Chan Zuckerberg Biohub have discovered cross reactive, broadly neutralizing human antibodies against all serotypes of dengue virus.
Dengue virus (DENV) is transmitted to humans through mosquitos and causes approximately 400 million global infections each year. DENV...
Published: 3/17/2023
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Inventor(s): Fabio Zanini, Derek Croote, Makeda Robinson, Leslie Goo, Stephen Quake, Shirit Einav, Krista McCutcheon
Keywords(s): Broadly Neutralizing Antibodies (bNAbs), Dengue, Flavivirus, Monoclonal Antibodies (mAbs), Single-cell Transcriptomics, Vaccine
Category(s): Technology Classifications > Biology
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DISCOVERY OF A HIGHLY THERMOSTABLE CAS9 VARIANT
DISCOVERY OF A HIGHLY THERMOSTABLE CAS9 VARIANT
Researchers at Stanford and the Chan Zuckerberg Biohub have discovered a Cas9 protein variant from Ignavibacterium that is thermostable at elevated temperatures.
The application of genome editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated...
Published: 3/17/2023
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Inventor(s): Stephen Quake, Stephanie Schmidt, Feiqiao Yu, Paul Blainey, Andrew May
Keywords(s): Cas9, CRISPR, Genome Editing, Nuclease, Themostable
Category(s): Technology Classifications > Biology
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NON-INVASIVE PREDICTION OF GESTATIONAL AGE AND PRETERM DELIVERY RISK USING MATERNAL CELL-FREE RNA
NON-INVASIVE PREDICTION OF GESTATIONAL AGE AND PRETERM DELIVERY RISK USING MATERNAL CELL-FREE RNA
Researchers at the Chan Zuckerberg Biohub, Stanford, and the Statens Serum Institute have developed methods for predicting gestational age and preterm delivery risk through analysis of maternal cell-free RNA (cfRNA) from blood samples.
Most clinicians...
Published: 12/5/2024
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Inventor(s): Mira Moufarrej, Stephen Quake, Mads Melbye, Thuy Ngo, Joan Camunas-Soler
Keywords(s): Blood, Cell Free RNA, cfRNA, Fetal Development, Gestational Age, Preterm Delivery Risk, Serum
Category(s): Technology Classifications > Biology
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