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METHODS FOR ULTRA-HIGH-THROUGHPUT PROFILING OF NUCLEIC ACID BINDING OR MODIFYING PROTEINS
METHODS FOR ULTRA-HIGH-THROUGHPUT PROFILING OF NUCLEIC ACID BINDING OR MODIFYING PROTEINS
Researchers at Stanford have developed a novel method for the mapping of nucleic acid binding or modifying proteins in a massively multiplexed manner.
Next generation sequencing (NGS) has allowed for sequence-agnostic sequencing and has revolutionized every...
Published: 4/22/2024
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Inventor(s): Polly Fordyce
Keywords(s): High-Throughput, Microfluidics, Protein-DNA Interactions
Category(s): Technology Classifications > Engineering
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HYDROGEL PURIFICATION OF CELL MATERIALS FOR PCR-ACTIVATED CELL SORTING
HYDROGEL PURIFICATION OF CELL MATERIALS FOR PCR-ACTIVATED CELL SORTING
Researchers at the NIH and UCSF have developed methods that detect RNA or DNA markers with single molecule sensitivity in cells of interest that allow rapid isolation of these cells or extracts/derivatives of these cells for in-depth transcriptomic, genomic or epigenomic analyses....
Published: 10/26/2023
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Inventor(s): Adam Abate, Iain Clark, Eli Boritz
Keywords(s): High-Throughput, Hydrogel, Microfluidic, Single Cell Genomics, Single Cell Transcriptomics
Category(s): Technology Classifications > Biology
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ARRAY PLATFORM FOR HIGH-THROUGHPUT ORGANOID PROFILING
ARRAY PLATFORM FOR HIGH-THROUGHPUT ORGANOID PROFILING
Researchers at Stanford have developed a new methodology for image processing that allows for high-throughput characterization of organoid phenotypes.
Organoids represent a major step forward in in vitro research studies into a myriad of disease states. 3D organoid models possess key advantages...
Published: 9/14/2023
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Inventor(s): Polly Fordyce, Christina Curtis, Alexandera Sockell, Wing Wong
Keywords(s): CRISPR, High-Throughput, Imaging, Organoid
Category(s): Technology Classifications > Biology
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SINGLE-CELL EPIGENOMIC PROFILING USING DROPLET FLUIDICS AND CHEMICALLY MODIFIED HYDROGELS
SINGLE-CELL EPIGENOMIC PROFILING USING DROPLET FLUIDICS AND CHEMICALLY MODIFIED HYDROGELS
Researchers at UCSF have developed materials and methods for high throughput single cell epigenomic sequencing using a capture/profiling approach with hydrogel scaffolds, thus facilitating a scale and form of epigenomic profiling beyond what has been previously...
Published: 7/6/2023
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Inventor(s): Adam Abate, Xiangpeng Li
Keywords(s): DNA Capture, Droplet, Epigenomic, High-Throughput, Hydrogel, Microfluidic, Single-Cell
Category(s): Technology Classifications > Biology
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METHODS FOR FRAGMENTING COMPLIMENTARY DNA
METHODS FOR FRAGMENTING COMPLIMENTARY DNA
Researchers at UCSF have discovered a new method for fragmenting complimentary DNA for sequencing applications.
Sequencing of nucleic acids is one of the most important and transformational methods in biomedical sciences. In recent years, high throughput sequencing has become commonplace in both academic and...
Published: 7/6/2023
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Inventor(s): Derek Bogdanoff, Chang Kim, Tomasz Nowakowski
Keywords(s): Barcode, cDNA, High-Throughput, Long-read Sequencing, Short Read Sequencing, Transposon, UMI
Category(s): Technology Classifications > Biology
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BEAD BASED ASSAY FOR SIMULTANEOUS DETECTION OF BIOMOLECULES
BEAD BASED ASSAY FOR SIMULTANEOUS DETECTION OF BIOMOLECULES
Researchers at Stanford University have developed methods for detecting one or more biomolecules within multiple samples in parallel.
Rapid and accessible point-of-care diagnostic testing is a cornerstone of public health management of infectious diseases. However, currently available diagnostic...
Published: 12/5/2024
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Inventor(s): Xavier Clave, Alexandros Drainas, Sizun Jiang, Garry Nolan, Julien Sage
Keywords(s): Barcodes, Biomolecule, High-Throughput, Multiplexed, Viral Diagnostics
Category(s): Technology Classifications > Biology
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METHOD FOR MASSIVELY PARALLEL SCREENING OF APTAMER SWITCHES
METHOD FOR MASSIVELY PARALLEL SCREENING OF APTAMER SWITCHES
Researchers at Stanford have developed a massively parallel screening strategy to screen for target-responsive molecular switches.
Target-responsive RNA- and DNA-based molecular switches have potential utility in a variety of technological applications. Such biosensors are typically...
Published: 3/17/2023
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Inventor(s): Hyongsok Soh
Keywords(s): Affinity Reagent, Aptamer, Base-Modified Nucleotide, Biomolecules, Biosensor System, Fluorescence, High-Throughput, Integrated Screening System, Molecular Switches, Non-Natural Nucleotide
Category(s): Technology Classifications > Biology
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METHOD AND SYSTEM FOR MULTI-VIEW EPISCOPIC SELECTIVE PLANE ILLUMINATION MICROSCOPE
METHOD AND SYSTEM FOR MULTI-VIEW EPISCOPIC SELECTIVE PLANE ILLUMINATION MICROSCOPE
Researchers at the Chan Zuckerberg Biohub have developed a single objective, multi-view light-sheet microscope with increased imaging depth and resolution.
Light-sheet microscopy, a type of selective plane illumination microscopy (SPIM), is an essential imaging...
Published: 3/17/2023
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Inventor(s): Bin Yang, Loic Royer
Keywords(s): Fluorescence, High-Throughput
Category(s): Technology Classifications > Engineering
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POINT-OF-CARE AND IMPROVED DETECTION AND QUANTIFICATION OF BIOMOLECULES
POINT-OF-CARE AND IMPROVED DETECTION AND QUANTIFICATION OF BIOMOLECULES
Researchers at UCSF and the Chan Zuckerberg Biohub have developed a workflow for accurate bulk quantitation of droplet digital PCR, which can be used in point-of-care clinical settings with minimal sample processing.
The quantitation of nucleic acids is important for clinical...
Published: 10/26/2024
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Inventor(s): Adam Abate, Xiangpeng Li
Keywords(s): Biomolecules, Diagnosis, Droplet Digital PCR, Fluorescence, High-Throughput, Microfluidics, SARS-CoV-2
Category(s): Technology Classifications > Biology
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MULTI-PARAMETRIC AND HIGH-THROUGHPUT SINGLE CELL ANALYSIS
MULTI-PARAMETRIC AND HIGH-THROUGHPUT SINGLE CELL ANALYSIS
Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have generated a method for performing multi-parametric and high-throughput single cell genomic and phenotypic analyses.
Single cell -omics, the study of diverse biological processes such as genome, RNA or protein expression...
Published: 3/17/2023
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Inventor(s): Polly Fordyce, Kara Brower, Sandy Klemm, William Greenleaf
Keywords(s): High-Throughput, Microfluidics, Single Cell, Single Cell Analysis, Single Cell Genomics
Category(s): Technology Classifications > Biology
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