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HUMAN CENTRAL NERVOUS SYSTEM (CNS) TARGETING AAV VARIANTS
HUMAN CENTRAL NERVOUS SYSTEM (CNS) TARGETING AAV VARIANTS
Researchers at UCSF and UC Berkeley have developed a recombinant adeno-associated virus (rAAV) with an altered capsid protein, where the rAAV exhibits greater ability to infect a central nervous system cell compared to wild-type AAVs.
The central nervous system (CNS) comprises a multitude...
Published: 10/26/2023
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Inventor(s): Tomasz Nowakowski, Galina Popava (Schmunk), David Schaffer, Danqing Zhu
Keywords(s): Adeno-associated Virus, Brain, Neuron
Category(s): Technology Classifications > Biology
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METHOD FOR PRODUCING A POPULATION OF SYMMETRICALLY BARCODED TRANSPOSOMES
METHOD FOR PRODUCING A POPULATION OF SYMMETRICALLY BARCODED TRANSPOSOMES
Researchers at UCSF have developed a method for producing a population of symmetrically barcoded transposomes that allow the reconstruction of a tagmented nucleic acid sequence without relying on alignment to a reference sequence.
Many next generation sequencing workflows rely...
Published: 7/6/2023
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Inventor(s): Derek Bogdanoff, Chang Kim, Tomasz Nowakowski
Keywords(s): Adaptor, Alignment, Barcoding, Next-Generation Sequencing, Sequence Reconstruction, Tagmentation, Transposase
Category(s): Technology Classifications > Biology
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METHODS FOR FRAGMENTING COMPLIMENTARY DNA
METHODS FOR FRAGMENTING COMPLIMENTARY DNA
Researchers at UCSF have discovered a new method for fragmenting complimentary DNA for sequencing applications.
Sequencing of nucleic acids is one of the most important and transformational methods in biomedical sciences. In recent years, high throughput sequencing has become commonplace in both academic and...
Published: 7/6/2023
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Inventor(s): Derek Bogdanoff, Chang Kim, Tomasz Nowakowski
Keywords(s): Barcode, cDNA, High-Throughput, Long-read Sequencing, Short Read Sequencing, Transposon, UMI
Category(s): Technology Classifications > Biology
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ADENO-ASSOCIATED VIRUS VIRIONS AND METHODS OF USE THEREOF
ADENO-ASSOCIATED VIRUS VIRIONS AND METHODS OF USE THEREOF
Researchers at UC Berkeley And. UCSF have developed a recombinant adeno-associated virus (rAAV) virion, comprising a variant AAV capsid protein, which can exhibit greater infectivity of a macrophage and has potential therapeutic applications.
Adeno-associated virus (AAV) belongs to the Parvoviridae...
Published: 4/20/2023
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Inventor(s): David Schaffer, Danqing Zhu, Tomasz Nowakowski, Galina Popava (Schmunk)
Keywords(s): Capsid, Delivery Method, Heterologous Nucleic Acid, Infectivity, Virion
Category(s): Technology Classifications > Biology
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