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MANIPULATING SPATIAL RNA LOCALIZATION
MANIPULATING SPATIAL RNA LOCALIZATION
Researchers at Stanford have developed an inducible and programmable CRISPR-mediated transcript organization (CRISPR-TO) method for repositioning RNAs to various desired subcellular compartments.
Spatial RNA transcriptomics, including subcellular mRNA localization, is a core mechanism for spatiotemporal regulation...
Published: 2/14/2024
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Inventor(s): Lei Qi, Mengting Han
Keywords(s): Localization, mRNA, Neuron
Category(s): Technology Classifications > Biology
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COMPOUNDS AS GABA RECEPTOR MODULATORS
COMPOUNDS AS GABA RECEPTOR MODULATORS
Researchers at UCSF have developed novel GABA-modulating pharmaceutical compounds that are potential therapeutics for the treatment of chronic pain.
Neurotransmitters are the building blocks of information transfer in the central nervous system and can modulate action potentials at the synapses of neurons...
Published: 12/5/2023
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Inventor(s): Matthew McCarroll, Jason Sello, David Kokel, Allan Basbaum, Jarret Weinrich
Keywords(s): Inhibitor, Neuron, Pain
Category(s): Technology Classifications > Biology
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HUMAN CENTRAL NERVOUS SYSTEM (CNS) TARGETING AAV VARIANTS
HUMAN CENTRAL NERVOUS SYSTEM (CNS) TARGETING AAV VARIANTS
Researchers at UCSF and UC Berkeley have developed a recombinant adeno-associated virus (rAAV) with an altered capsid protein, where the rAAV exhibits greater ability to infect a central nervous system cell compared to wild-type AAVs.
The central nervous system (CNS) comprises a multitude...
Published: 10/26/2023
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Inventor(s): Tomasz Nowakowski, Galina Popava (Schmunk), David Schaffer, Danqing Zhu
Keywords(s): Adeno-associated Virus, Brain, Neuron
Category(s): Technology Classifications > Biology
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METHODS FOR GENERATING PARVALBUMIN-POSITIVE INTERNEURONS
METHODS FOR GENERATING PARVALBUMIN-POSITIVE INTERNEURONS
Researchers at UCSF and have developed a method for generating an enriched population of parvalbumin-positive interneurons.
Parvalbumin-positive interneurons are the largest subpopulation of inhibitory interneurons in the cerebral cortex, and are involved in a variety of neurodevelopmental and...
Published: 5/18/2023
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Inventor(s): Mohammed Mostajo-Radji, Alex Pollen
Keywords(s): Brain, Cortical, Interneurons, Neuron, Organoid, Parvalbumin-Positive
Category(s): Technology Classifications > Biology
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