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HUMAN CENTRAL NERVOUS SYSTEM (CNS) TARGETING AAV VARIANTS
HUMAN CENTRAL NERVOUS SYSTEM (CNS) TARGETING AAV VARIANTS
Researchers at UCSF and UC Berkeley have developed a recombinant adeno-associated virus (rAAV) with an altered capsid protein, where the rAAV exhibits greater ability to infect a central nervous system cell compared to wild-type AAVs.
The central nervous system (CNS) comprises a multitude...
Published: 10/26/2023
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Inventor(s): Tomasz Nowakowski, Galina Popava (Schmunk), David Schaffer, Danqing Zhu
Keywords(s): Adeno-associated Virus, Brain, Neuron
Category(s): Technology Classifications > Biology
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COMPOSITIONS AND METHODS RELATED TO TRANSCOBALAMIN RECEPTOR AUTOANTIBODIES
COMPOSITIONS AND METHODS RELATED TO TRANSCOBALAMIN RECEPTOR AUTOANTIBODIES
Researchers at CZ Biohub SF and UCSF have developed methods and kits to detect autoantibodies targeting the transcobalamin receptor CD320, which is associated with neurological symptoms in certain patients, as well as methods to treat patients with this condition.
Vitamin...
Published: 10/26/2023
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Inventor(s): John Pluvinage, Michael Wilson, Joseph DeRisi, Samuel Pleasure
Keywords(s): Autoantibody, Brain, Vitamin B12
Category(s): Technology Classifications > Biology
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METHODS FOR GENERATING PARVALBUMIN-POSITIVE INTERNEURONS
METHODS FOR GENERATING PARVALBUMIN-POSITIVE INTERNEURONS
Researchers at UCSF and have developed a method for generating an enriched population of parvalbumin-positive interneurons.
Parvalbumin-positive interneurons are the largest subpopulation of inhibitory interneurons in the cerebral cortex, and are involved in a variety of neurodevelopmental and...
Published: 5/18/2023
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Inventor(s): Mohammed Mostajo-Radji, Alex Pollen
Keywords(s): Brain, Cortical, Interneurons, Neuron, Organoid, Parvalbumin-Positive
Category(s): Technology Classifications > Biology
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