Search Results - joseph+derisi

6 Results Sort By:
­AUTOANTIBODIES AS BIOMARKERS FOR LIPODYSTROPHY
­AUTOANTIBODIES AS BIOMARKERS FOR LIPODYSTROPHY Researchers at UCSF and the Chan Zuckerberg Biohub have developed methods to identify a subject that is at risk of developing autoimmune-related lipodystrophy. Lipodystrophy is a clinical phenotype defined by a reduction in subcutaneous fat or adipose tissue. Excessive fat loss can lead to an imbalance...
Published: 8/15/2022   |   Inventor(s): Caleigh Mandel-Brehm, Joseph DeRisi, Mark Anderson
Keywords(s): Antibody, Autoantibody, Autoimmune, Biomolecules, Diagnosis, IgG, Immunotherapy, Lipodystrophy
Category(s): Technology Classifications > Biology
ENGINEERED MULTI-SEGMENTED RNA VIRUSES FOR LARGE-SCALE COMBINATORIAL GENETIC SCREENING
­ENGINEERED MULTI-SEGMENTED RNA VIRUSES FOR LARGE-SCALE COMBINATORIAL GENETIC SCREENING Researchers at UCSF and the Chan Zuckerberg Biohub have engineered multi-segmented RNA viruses for use in generating large-scale combinatorial libraries. Targeted genetic screening, for example using CRISPR-based systems, is useful to dissect biological pathways....
Published: 5/19/2022   |   Inventor(s): Joseph DeRisi, Hanna Retallack
Keywords(s): Cas9, CRISPR, CRISPRi, Integrated Screening System, Nuclease
Category(s): Technology Classifications > Biology
AUTOANTIBODIES AS BIOMARKERS FOR AUTOIMMUNE POLYGLANDULAR SYNDROME TYPE 1
AUTOANTIBODIES AS BIOMARKERS FOR AUTOIMMUNE POLYGLANDULAR SYNDROME TYPE 1 Researchers at UCSF and the Chan Zuckerberg Biohub have identified multiple common autoantibody targets in APS1 patients through proteome-wide programmable phage-display. The identification of autoantigens remains a critical challenge for understanding and treating autoimmune...
Published: 1/14/2022   |   Inventor(s): Sara Vazquez, Mark Anderson, Joseph DeRisi
Keywords(s): Antibody, Autoantibody, Diagnosis, Particle Display, Serum
Category(s): Technology Classifications > Biology
METHODS, COMPOSITIONS AND SYSTEMS FOR PROFILING OR PREDICTING IMMUNE RESPONSE
METHODS, COMPOSITIONS AND SYSTEMS FOR PROFILING OR PREDICTING IMMUNE RESPONSE Researchers at Avail Bio, Inc., UCSF and the Chan Zuckerberg Biohub have developed a proteomic technology for capturing the immune response against non-wild type antigens. Immuno-oncologic research demonstrating tumor recognition by the immune system has led to the development...
Published: 6/24/2021   |   Inventor(s): Nima Emami, Clinton Cario, Joseph DeRisi, John Witte
Keywords(s): Antibody, Cancer, Immunotherapy, Oncology, Particle Display
Category(s): Technology Classifications > Biology
GENE THERAPY FOR IMMUNO-ONCOLOGY APPLICATIONS
GENE THERAPY FOR IMMUNO-ONCOLOGY APPLICATIONS Researchers at the Chan Zuckerberg Biohub and UCSF have developed viral gene therapy delivery systems for therapeutic immuno-oncology applications. Glioblastoma is the most common and deadliest primary malignant brain cancer with an overall median survival of 14.6 months. Therapies currently in use, and...
Published: 12/16/2020   |   Inventor(s): Nicole Paulk, Joseph DeRisi, David Raleigh
Keywords(s): Convection Enhanced Delivery, Gene Therapy, Glioblastoma, Immuno-Oncology, Interferon (IFN), Recombinant Adenoviral-Associated Virus (rAAV)
Category(s): Technology Classifications > Biology
AUTOANTIBODIES AS BIOMARKER OF PARANEOPLASTIC  ENCEPHALITIS ASSOCIATED WITH TESTICULAR CANCER
AUTOANTIBODIES AS BIOMARKER OF PARANEOPLASTIC ENCEPHALITIS ASSOCIATED WITH TESTICULAR CANCER Researchers at the Chan Zuckerberg Biohub, UCSF and the Mayo Clinic have discovered a novel biomarker for an autoimmune disease that affects patients with testicular cancer. The disease, known as “testicular cancer-associated paraneoplastic encephalitis,”...
Published: 11/9/2020   |   Inventor(s): Joseph DeRisi, Michael Wilson, Caleigh Mandel-Brehm, Brian O'Donovan, Sean Pittock, Divyanshu Dubey, Thomas Kryzer, Vanda Lennon, Andrew McKeon
Keywords(s): Antibody, Autoantibody, Diagnosis, KLHL11, Neurology, Testicular Cancer
Category(s): Technology Classifications > Biology