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COMPOSITIONS AND METHODS RELATED TO TRANSCOBALAMIN RECEPTOR AUTOANTIBODIES
COMPOSITIONS AND METHODS RELATED TO TRANSCOBALAMIN RECEPTOR AUTOANTIBODIES
Researchers at CZ Biohub SF and UCSF have developed methods and kits to detect autoantibodies targeting the transcobalamin receptor CD320, which is associated with neurological symptoms in certain patients, as well as methods to treat patients with this condition.
Vitamin...
Published: 10/26/2023
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Inventor(s): John Pluvinage, Michael Wilson, Joseph DeRisi, Samuel Pleasure
Keywords(s): Autoantibody, Brain, Vitamin B12
Category(s): Technology Classifications > Biology
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ANTIBODIES TO IL1RN AS MARKERS OF PRETERM BIRTH
ANTIBODIES TO IL1RN AS MARKERS OF PRETERM BIRTH
Researchers at CZ Biohub SF and UCSF have discovered a novel biomarker of pre-term birth.
Little is known about pre-term delivery risk and more specifically the immunological processes that allow for tolerance of a semi-allogenic fetus within the mother’s body. However, the processes that govern...
Published: 8/17/2023
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Inventor(s): Elze Rackaityte, Joseph DeRisi
Keywords(s): Antibody, Biomarker, Preterm Delivery Risk
Category(s): Technology Classifications > Biology
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LOWER RESPIRATORY TRACT INFECTION DIAGNOSTICS
LOWER RESPIRATORY TRACT INFECTION DIAGNOSTICS
Researchers at UCSF, CZ Biohub SF, CZI and University of Colorado have developed a host/pathogen classifier to differentiate patients with lower respiratory tract infections (LRTI) from those with non-infectious acute respiratory illnesses.
Lower respiratory tract infections (LRTI) are a leading cause...
Published: 5/18/2023
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Inventor(s): Charles (Chaz) Langelier, Peter Mourani, John Kamm, Eran Mick, Alexandra Tsitsiklis, Katrina Kalantar, Lilliam Ambroggio, Joseph DeRisi
Keywords(s): Disease Classifier, Pathogen, Respiratory
Category(s): Technology Classifications > Biology
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METHOD AND SYSTEM FOR LABEL-FREE IMAGING AND CLASSIFICATION OF MALARIA PARASITES
METHOD AND SYSTEM FOR LABEL-FREE IMAGING AND CLASSIFICATION OF MALARIA PARASITES
Researchers at the CZ Biohub SF have developed an improved method of detecting and classifying malarial parasitemia in blood samples that is cost-efficient and readily able to be implemented in low-resource settings.
Accurate, timely, and cost-effective diagnostics...
Published: 3/17/2023
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Inventor(s): Paul Lebel, Rafael Gómez-Sjöberg, Joseph DeRisi, Jenny Folkesson
Keywords(s): Deep Learning, Diagnostics, Label-Free, Malaria, P. Falciparum, Visible Light Microscopy
Category(s): Technology Classifications > Biology
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AUTOANTIBODIES AS BIOMARKERS FOR LIPODYSTROPHY
AUTOANTIBODIES AS BIOMARKERS FOR LIPODYSTROPHY
Researchers at UCSF and the Chan Zuckerberg Biohub have developed methods to identify a subject that is at risk of developing autoimmune-related lipodystrophy.
Lipodystrophy is a clinical phenotype defined by a reduction in subcutaneous fat or adipose tissue. Excessive fat loss can lead to an imbalance...
Published: 3/17/2023
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Inventor(s): Caleigh Mandel-Brehm, Joseph DeRisi, Mark Anderson
Keywords(s): Antibody, Autoantibody, Autoimmune, Biomolecules, Diagnosis, IgG, Immunotherapy, Lipodystrophy
Category(s): Technology Classifications > Biology
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AUTOANTIBODIES AS BIOMARKERS FOR AUTOIMMUNE POLYGLANDULAR SYNDROME TYPE 1
AUTOANTIBODIES AS BIOMARKERS FOR AUTOIMMUNE POLYGLANDULAR SYNDROME TYPE 1
Researchers at UCSF and the Chan Zuckerberg Biohub have identified multiple common autoantibody targets in APS1 patients through proteome-wide programmable phage-display.
The identification of autoantigens remains a critical challenge for understanding and treating autoimmune...
Published: 3/17/2023
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Inventor(s): Sara Vazquez, Mark Anderson, Joseph DeRisi
Keywords(s): Antibody, Autoantibody, Diagnosis, Particle Display, Serum
Category(s): Technology Classifications > Biology
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METHODS, COMPOSITIONS AND SYSTEMS FOR PROFILING OR PREDICTING IMMUNE RESPONSE
METHODS, COMPOSITIONS AND SYSTEMS FOR PROFILING OR PREDICTING IMMUNE RESPONSE
Researchers at Avail Bio, Inc., UCSF and the Chan Zuckerberg Biohub have developed a proteomic technology for capturing the immune response against non-wild type antigens.
Immuno-oncologic research demonstrating tumor recognition by the immune system has led to the development...
Published: 6/1/2023
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Inventor(s): Nima Emami, Clinton Cario, Joseph DeRisi, John Witte
Keywords(s): Antibody, Cancer, Immunotherapy, Oncology, Particle Display
Category(s): Technology Classifications > Biology
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GENE THERAPY FOR IMMUNO-ONCOLOGY APPLICATIONS
GENE THERAPY FOR IMMUNO-ONCOLOGY APPLICATIONS
Researchers at the Chan Zuckerberg Biohub and UCSF have developed viral gene therapy delivery systems for therapeutic immuno-oncology applications.
Glioblastoma is the most common and deadliest primary malignant brain cancer with an overall median survival of 14.6 months. Therapies currently in use, and...
Published: 5/31/2023
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Inventor(s): Nicole Paulk, Joseph DeRisi, David Raleigh
Keywords(s): Convection Enhanced Delivery, Gene Therapy, Glioblastoma, Immuno-Oncology, Interferon (IFN), Recombinant Adenoviral-Associated Virus (rAAV)
Category(s): Technology Classifications > Biology
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AUTOANTIBODIES AS BIOMARKER OF PARANEOPLASTIC ENCEPHALITIS ASSOCIATED WITH TESTICULAR CANCER
AUTOANTIBODIES AS BIOMARKER OF PARANEOPLASTIC ENCEPHALITIS ASSOCIATED WITH TESTICULAR CANCER
Researchers at the Chan Zuckerberg Biohub, UCSF and the Mayo Clinic have discovered a novel biomarker for an autoimmune disease that affects patients with testicular cancer. The disease, known as “testicular cancer-associated paraneoplastic encephalitis,”...
Published: 3/17/2023
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Inventor(s): Joseph DeRisi, Michael Wilson, Caleigh Mandel-Brehm, Brian O'Donovan, Sean Pittock, Divyanshu Dubey, Thomas Kryzer, Vanda Lennon, Andrew McKeon
Keywords(s): Antibody, Autoantibody, Diagnosis, KLHL11, Neurology, Testicular Cancer
Category(s): Technology Classifications > Biology
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