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PERILIPIN-1 SPECIFIC T CELLS FOR SELECTIVE FAT TARGETING
Researchers at UCSF and CZ Biohub SF have described cells expressing a heterologous T-cell receptor, that binds to an adipose-specific protein perilipin 1 peptide complex, thereby enabling selecting targeting of fat cells.
T cell tolerance is enforced in the thymus through the expression of a wide array of self proteins called tissue-specific antigens...
Published: 10/23/2025
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Inventor(s): Mark Anderson, Irina Proekt, Joseph DeRisi
Keywords(s): Autoantibody, Autoimmune, Therapeutic
Category(s): Technology Classifications > Biology
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BACTERIA-ENGINEERED TO ELICIT ANTIGEN-SPECIFIC T-CELLS
BACTERIA-ENGINEERED TO ELICIT ANTIGEN-SPECIFIC T-CELLS
Researchers at Stanford have developed a new avenue for stimulating T effector and Treg immune cells in an antigen-specific manner.
Commensal microbiota have been shown to functionally regulate the innate and adaptive immune systems and must establish distinct niches at barrier sites throughout...
Published: 3/3/2025
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Inventor(s): Michael Fischbach, Kazuki Nagashima, Yiyin Chen, Djenet Bousbaine
Keywords(s): Autoimmune, Bacteria, T-Cell Activation
Category(s): Technology Classifications > Biology
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BACTERIA-ENGINEERED TO ELICIT ANTIGEN-SPECIFIC T-CELLS
BACTERIA-ENGINEERED TO ELICIT ANTIGEN-SPECIFIC T-CELLS
Researchers at Stanford have developed a new avenue for stimulating T effector and Treg immune cells in an antigen-specific manner.
Commensal microbiota have been shown to functionally regulate the innate and adaptive immune systems and must establish distinct niches at barrier sites throughout...
Published: 10/6/2023
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Inventor(s): Michael Fischbach, Kazuki Nagashima, Yiyin Chen
Keywords(s): Autoimmune, Bacteria, T-Cell Activation
Category(s): Technology Classifications > Biology
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AUTOANTIBODIES AS BIOMARKERS FOR LIPODYSTROPHY
AUTOANTIBODIES AS BIOMARKERS FOR LIPODYSTROPHY
Researchers at UCSF and the Chan Zuckerberg Biohub have developed methods to identify a subject that is at risk of developing autoimmune-related lipodystrophy.
Lipodystrophy is a clinical phenotype defined by a reduction in subcutaneous fat or adipose tissue. Excessive fat loss can lead to an imbalance...
Published: 12/5/2024
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Inventor(s): Caleigh Mandel-Brehm, Joseph DeRisi, Mark Anderson
Keywords(s): Antibody, Autoantibody, Autoimmune, Biomolecules, Diagnosis, IgG, Immunotherapy, Lipodystrophy
Category(s): Technology Classifications > Biology
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