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METHOD FOR MASSIVELY PARALLEL SCREENING OF APTAMER SWITCHES
METHOD FOR MASSIVELY PARALLEL SCREENING OF APTAMER SWITCHES
Researchers at Stanford have developed a massively parallel screening strategy to screen for target-responsive molecular switches.
Target-responsive RNA- and DNA-based molecular switches have potential utility in a variety of technological applications. Such biosensors are typically...
Published: 3/17/2023
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Inventor(s): Hyongsok Soh
Keywords(s): Affinity Reagent, Aptamer, Base-Modified Nucleotide, Biomolecules, Biosensor System, Fluorescence, High-Throughput, Integrated Screening System, Molecular Switches, Non-Natural Nucleotide
Category(s): Technology Classifications > Biology
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A TUNABLE PROXIMITY ASSAY THAT CAN OVERCOME DILUTIONAL NON-LINEARITY
A TUNABLE PROXIMITY ASSAY THAT CAN OVERCOME DILUTIONAL NON-LINEARITY
Researchers at Stanford have developed a tunable proximity assay with a wide dynamic range that can detect multiple analytes in a single sample.
Blood-based quantification of protein biomarkers is a standard tool for the prediction, diagnosis, and monitoring of disease. Physiological...
Published: 3/17/2023
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Inventor(s): Hyongsok Soh
Keywords(s): Affinity Reagent, Antibody, Aptamer, Biomolecules, Biosensor System, Blood, Serum
Category(s): Technology Classifications > Biology
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METHOD FOR COMBINED GENOME METHYLATION AND VARIATION ANALYSES
METHOD FOR COMBINED GENOME METHYLATION AND VARIATION ANALYSES
Researchers at Stanford have developed improved methods for combined analyses of epigenetics and nucleotide variation in single cells.
Single cell genomic sequencing has allowed characterization of the diversity and evolution of cells within tissues. Recent advances in whole genome...
Published: 12/5/2024
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Inventor(s): Veronica Gonzalez-Pena, Charles Gawad
Keywords(s): Biomolecules, Epigenetics, Methylation, Single Cell, Single Cell Analysis, Single Cell Genomics
Category(s): Technology Classifications > Biology
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AUTOANTIBODIES AS BIOMARKERS FOR LIPODYSTROPHY
AUTOANTIBODIES AS BIOMARKERS FOR LIPODYSTROPHY
Researchers at UCSF and the Chan Zuckerberg Biohub have developed methods to identify a subject that is at risk of developing autoimmune-related lipodystrophy.
Lipodystrophy is a clinical phenotype defined by a reduction in subcutaneous fat or adipose tissue. Excessive fat loss can lead to an imbalance...
Published: 12/5/2024
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Inventor(s): Caleigh Mandel-Brehm, Joseph DeRisi, Mark Anderson
Keywords(s): Antibody, Autoantibody, Autoimmune, Biomolecules, Diagnosis, IgG, Immunotherapy, Lipodystrophy
Category(s): Technology Classifications > Biology
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METHODS AND SYSTEM FOR SPECTRAL IMAGING OF DENSITY, ANISTROPY, AND ORIENTATION
METHODS AND SYSTEM FOR SPECTRAL IMAGING OF DENSITY, ANISTROPY, AND ORIENTATION
Researchers at the Chan Zuckerberg Biohub have developed an imaging module and computational algorithms for high-speed spectral quantitative imaging of density and anisotropy in fluorescence and label-free contrasts.
Microscopy is central to biological research and...
Published: 3/17/2023
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Inventor(s): Shalin Mehta, Ivan Ivanov, Li-Hao Yeh
Keywords(s): Anisotropy, Biomolecules, Density, Microscopy, Optical Imaging, Polarization
Category(s): Technology Classifications > Engineering
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METHOD AND SYSTEM FOR QUANTITATIVE THREE-DIMENSIONAL MEASUREMENT OF DENSITY, ANISOTROPY, AND ORIENTATION WITHOUT LABEL
METHOD AND SYSTEM FOR QUANTITATIVE THREE-DIMENSIONAL MEASUREMENT OF DENSITY, ANISOTROPY, AND ORIENTATION WITHOUT LABEL
Researchers at the Chan Zuckerberg Biohub have developed a label-free computational imaging method for measuring optical properties of a specimen.
Biological architecture is intrinsically tensorial. The permittivity tensor (PT)...
Published: 3/17/2023
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Inventor(s): Shalin Mehta, Ivan Ivanov, Li-Hao Yeh
Keywords(s): Anisotropy, Biomolecules, Density, Microscopy, Optical Imaging, Polarization
Category(s): Technology Classifications > Engineering
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NUCLEIC ACID SEQUENCE DETECTION BY MEASURING FREE MONORIBONUCLEOTIDES GENERATED BY ENDONUCLEASE COLLATERAL CLEAVAGE ACTIVITY
NUCLEIC ACID SEQUENCE DETECTION BY MEASURING FREE MONORIBONUCLEOTIDES GENERATED BY ENDONUCLEASE COLLATERAL CLEAVAGE ACTIVITY
Researchers at the Chan Zuckerberg Biohub have developed an improved method to detect target nucleic acid sequences in a biological sample, NANCI™.
CRISPR-associated protein (Cas) technology is a sequence-specific...
Published: 3/17/2023
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Inventor(s): Emily Crawford, Amy Lyden
Keywords(s): Biomolecules, Biosensor System, CRISPR, Diagnosis, Nuclease
Category(s): Technology Classifications > Biology
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QUANTIFICATION OF CELLULAR PROTEINS USING BARCODED BINDING MOIETIES
QUANTIFICATION OF CELLULAR PROTEINS USING BARCODED BINDING MOIETIES
Researchers at Stanford have developed a method enabling quantification of intracellular protein levels using oligonucleotide-barcoded antibodies.
Multiplexing single cell technologies affords researchers the ability to characterize cell states and identify gene regulatory programs...
Published: 3/17/2023
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Inventor(s): William Greenleaf, Amy Chen
Keywords(s): Affinity Reagent, Antibody, Biomolecules, Integrated Screening System, ScRNA-seq, Single Cell, Single Cell Analysis, Single Cell Genomics, Single Cell RNA Sequencing, Single-cell Transcriptomics
Category(s): Technology Classifications > Biology
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COMPOSITIONS AND METHODS FOR TREATING RNA VIRUS INFECTION
COMPOSITIONS AND METHODS FOR TREATING RNA VIRUS INFECTION
Researchers at Stanford have developed a method of treating or preventing an infection from an RNA virus.
Viral pathogens are an ongoing threat to public health worldwide. Upon infection, RNA viruses must remodel host machinery to promote viral protein production while also suppressing host...
Published: 12/6/2024
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Inventor(s): Raul Andino-Pavlovsky, Judith Frydman
Keywords(s): Biomolecules, Dengue, Dengue Virus, Flavivirus, Proteostasis, Ribosomes
Category(s): Technology Classifications > Biology
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CONTINUOUS REAL-TIME MONITORING OF BIOMOLECULES IN LIVE SUBJECTS
CONTINUOUS REAL-TIME MONITORING OF BIOMOLECULES IN LIVE SUBJECTS
Researchers at Stanford have developed methods for the continuous real-time monitoring of biomolecules in live subjects.
Real-time biosensors that can continuously measure circulating biomolecules in vivo would revolutionize the healthcare system by enabling truly personalized...
Published: 3/17/2023
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Inventor(s): Hyongsok Soh, Mahla Poudineh, Jing Pan
Keywords(s): Affinity Reagent, Antibody, Aptamer, Biomolecules, Biosensor System, Blood, Microfluidics
Category(s): Technology Classifications > Engineering
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