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INTEGRATED HOST-MICROBE METAGENOMICS OF CELL-FREE NUCLEIC ACID FOR SEPSIS DIAGNOSIS
INTEGRATED HOST-MICROBE METAGENOMICS OF CELL-FREE NUCLEIC ACID FOR SEPSIS DIAGNOSIS
Researchers at UCSF and the Chan Zuckerberg Institute have developed a single-sample metagenomic approach combining host transcriptional profiling with unbiased pathogen detection to improve sepsis diagnosis.
Sepsis causes 20% of all deaths globally and contributes...
Published: 9/14/2023
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Inventor(s): Charles (Chaz) Langelier, Katrina Kalantar, Lucile Neyton, Carolyn Calfee
Keywords(s): Cell-Free DNA, cfDNA, Diagnosis, Next Generation Sequencing (NGS), Sepsis
Category(s): Technology Classifications > Biology
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DEVELOPMENT AND VALIDATION OF A 2-GENE HOST-VIRAL TRANSCRIPTOMIC CLASSIFIER FOR ENHANCED COVID-19 DIAGNOSIS
DEVELOPMENT AND VALIDATION OF A 2-GENE HOST-VIRAL TRANSCRIPTOMIC CLASSIFIER FOR ENHANCED COVID-19 DIAGNOSIS
Researchers at UCSF and CZ Biohub SF have developed a two gene host signature that detects COVID infection regardless of the causative viral variant.
Though COVID-19 has largely transitioned from pandemic to endemic status, viral variants of...
Published: 5/18/2023
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Inventor(s): Charles (Chaz) Langelier
Keywords(s): Classifier, COVID, Host Determinants, qPCR, SARS-CoV-2, Viral Diagnostics
Category(s): Technology Classifications > Biology
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LOWER RESPIRATORY TRACT INFECTION DIAGNOSTICS
LOWER RESPIRATORY TRACT INFECTION DIAGNOSTICS
Researchers at UCSF, CZ Biohub SF, CZI and University of Colorado have developed a host/pathogen classifier to differentiate patients with lower respiratory tract infections (LRTI) from those with non-infectious acute respiratory illnesses.
Lower respiratory tract infections (LRTI) are a leading cause...
Published: 5/18/2023
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Inventor(s): Charles (Chaz) Langelier, Peter Mourani, John Kamm, Eran Mick, Alexandra Tsitsiklis, Katrina Kalantar, Lilliam Ambroggio, Joseph DeRisi
Keywords(s): Disease Classifier, Pathogen, Respiratory
Category(s): Technology Classifications > Biology
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