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HUMAN CENTRAL NERVOUS SYSTEM (CNS) TARGETING AAV VARIANTS
HUMAN CENTRAL NERVOUS SYSTEM (CNS) TARGETING AAV VARIANTS
Researchers at UCSF and UC Berkeley have developed a recombinant adeno-associated virus (rAAV) with an altered capsid protein, where the rAAV exhibits greater ability to infect a central nervous system cell compared to wild-type AAVs.
The central nervous system (CNS) comprises a multitude...
Published: 10/26/2023
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Inventor(s): Tomasz Nowakowski, Galina Popava (Schmunk), David Schaffer, Danqing Zhu
Keywords(s): Adeno-associated Virus, Brain, Neuron
Category(s): Technology Classifications > Biology
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MACHINE LEARNING GUIDED DESIGN OF VIRAL VECTOR LIBRARIES
MACHINE LEARNING GUIDED DESIGN OF VIRAL VECTOR LIBRARIES
Researchers at UC Berkeley have developed a machine learning model that can aide in the design of more efficient viral vector libraries.
Directed evolution of biomolecules to generate large numbers of randomized variants is an important innovation in biochemistry. This methodology can be applied...
Published: 8/17/2023
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Inventor(s): David Schaffer, Jennifer Listgarten, Danqing Zhu, David Brookes
Keywords(s): Machine Learning, Recombinant Adenoviral-Associated Virus (rAAV), Vector
Category(s): Technology Classifications > Software
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ADENO-ASSOCIATED VIRUS VIRIONS AND METHODS OF USE THEREOF
ADENO-ASSOCIATED VIRUS VIRIONS AND METHODS OF USE THEREOF
Researchers at UC Berkeley And. UCSF have developed a recombinant adeno-associated virus (rAAV) virion, comprising a variant AAV capsid protein, which can exhibit greater infectivity of a macrophage and has potential therapeutic applications.
Adeno-associated virus (AAV) belongs to the Parvoviridae...
Published: 4/20/2023
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Inventor(s): David Schaffer, Danqing Zhu, Tomasz Nowakowski, Galina Popava (Schmunk)
Keywords(s): Capsid, Delivery Method, Heterologous Nucleic Acid, Infectivity, Virion
Category(s): Technology Classifications > Biology
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