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PREDICTING 3D GENOME ARCHITECTURE FROM SINGLE-MOLECULE SEQUENCING DATA
Researchers at Stanford have developed FiberFold, a computational tool enabling the rapid analysis of 3D chromatin architecture in conjunction with chromatin accessibility, CTCF binding, CpG methylation, and underlying genetic architecture.
To gain a comprehensive understanding of the genomic regulatory landscape, it is essential to investigate various...
Published: 10/23/2025
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Inventor(s): Nicolas Altemose, Danilo Dubocanin
Keywords(s): Chromatin, Genomic, Machine Learning, Sequencing
Category(s): Technology Classifications > Biology
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MULTI-MODAL, SAME-CELL ASSAY FOR SEQUENCING AND PROTEIN DETECTION
Researchers at UC Berkeley have developed a platform that enables unified proteomic and nucleic acid-based omics analysis from the same cell.
Current multiplex assays, such as those relying on commercial systems like 10XGenomics, are limited in their ability to detect surface or intra-nuclear proteins and they require prior knowledge of target proteins...
Published: 10/23/2025
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Inventor(s): Amy Herr, Thi Thao Lam
Keywords(s): Multiplex, Nucleic Acid, Protein, Sequencing, Single Cell
Category(s): Technology Classifications > Biology
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SINGLE-CELL CULTURE AND SEQUENCING WITH LIPID-MODIFIED OLIGOS
SINGLE-CELL CULTURE AND SEQUENCING WITH LIPID-MODIFIED OLIGOS
Researchers at UCSF have developed methods for sequencing a single cell from a cell culture sample and obtaining morphologic or phenotypic measurements and information by combining sequencing approaches and spatial hashing (e.g. barcoding) at a single cell level.
There exists a need in...
Published: 7/27/2023
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Inventor(s): Kai-Chun Chang, Adam Abate
Keywords(s): Lipid-Modified, Oligonucleotides, Sequencing, Single Cell
Category(s): Technology Classifications > Biology
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PARTITIONING CELLS FOR HIGH-THROUGHPUT SINGLE-CELL SEQUENCING
PARTITIONING CELLS FOR HIGH-THROUGHPUT SINGLE-CELL SEQUENCING
Researchers at UCSF have developed a method for high throughput single-cell multi-omic sequencing that is rapid, simple to operate, and offers key innovations over existing technologies.
Single-cell sequencing technologies refer to the methods to obtain genomics, transcriptomics or multi-omics...
Published: 4/20/2023
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Inventor(s): Adam Abate, Xiangpeng Li, Benjamin Demaree
Keywords(s): Genomic DNA, Hydrogel, Microfluidic, Partitioning, Sequencing, Single-Cell, Transcriptomics
Category(s): Technology Classifications > Biology
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