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VOLUME IMAGING OF BIOLOGICAL SPECIMENS BY PHOTOCHEMICAL SECTIONING
VOLUME IMAGING OF BIOLOGICAL SPECIMENS BY PHOTOCHEMICAL SECTIONING
Researchers at UC Berkeley and University of Illinois, Chicago have developed a nanoscale volume fluorescence imaging method that enables high-resolution imaging of large tissue volumes.
Hydrogel-based tissue clearing and expansion techniques have improved the ability to study cellular...
Published: 11/6/2024
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Inventor(s): Gokul Upadhyayula, RuiXuan Gao
Keywords(s): Hydrogel, Imaging, Photodegradable
Category(s): Technology Classifications > Biology
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3D PRINTING OF ORGANOID SLURRIES
3D PRINTING OF ORGANOID SLURRIES
Researchers at Stanford have developed methods for 3D printing and post-biomanufacturing of organoid slurries in a high yield stress matrix.
Biomanufactured tissues and organs on demand has been a long-standing challenge in the field of tissue engineering. Despite the advancements allowed by 3D bioprinting, current...
Published: 11/6/2024
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Inventor(s): Mark Syklyar-Scott, Jianyi Du
Keywords(s): Bioink, Matrix, Organoid, Printing
Category(s): Technology Classifications > Biology
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GENETICALLY ENCODED LYSOSOME TARGETING CHIMERAS FOR CELL-MEDIATED DELIVERY
GENETICALLY ENCODED LYSOSOME TARGETING CHIMERAS FOR CELL-MEDIATED DELIVERY
Researchers at Stanford have developed fully genetically-encodable lysosome-targeting chimeras which allow for the targeted delivery of various proteins into receiver cells.
Lysosome-targeted degradation is an emerging therapeutic modality that facilitates the degradation...
Published: 11/6/2024
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Inventor(s): Jonathan Yang, Carolyn Bertozzi, Alice Ting
Keywords(s): Fusion Protein, Lysosome
Category(s): Technology Classifications > Biology
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COMPOSITIONS AND METHODS RELATED TO CORONAVIRUS THERAPIES
COMPOSITIONS AND METHODS RELATED TO CORONAVIRUS THERAPIES
Researchers at Stanford have developed fusion proteins, containing ACE2 domain linked to a fragment of non-neutralizing anti-SARS-CoV-2 spike protein antibody, with a greater breadth of protection than previously described similar fusion proteins.
Coronaviruses are a large family of viruses...
Published: 11/6/2024
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Inventor(s): Peter Kim, Adrian Hugenmatter, Ashley Utz, Matthew Armbrust
Keywords(s): ACE2, Antibody, Coronavirus, Neutralizing, Spike
Category(s): Technology Classifications > Biology
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SELECTIVE SENSITIZATION OF CANCER CELLS TO ELIMINATION BY CYTOTOXIC LYMPHOCYTES
SELECTIVE SENSITIZATION OF CANCER CELLS TO ELIMINATION BY CYTOTOXIC LYMPHOCYTES
Researchers at Stanford University have developed a novel method for the treatment and prevention of cancer.
The immune system is an integral part of the human body’s response to outside threats, including cancer. Specifically, cytotoxic CD8+ T cells have been...
Published: 9/24/2024
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Inventor(s): Reece Akana
Keywords(s): Cancer, Immuno-Oncology, T-Cell Activation
Category(s): Technology Classifications > Biology
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COMPOSITIONS AND METHODS FOR RE-ACTIVATION OF DYSFUNCTIONAL SKELETAL STEM CELLS
COMPOSITIONS AND METHODS FOR RE-ACTIVATION OF DYSFUNCTIONAL SKELETAL STEM CELLS
Researchers at Stanford University have developed a novel therapeutic avenue for the treatment of osteoporosis and other musculoskeletal diseases.
Musculoskeletal disease incidence rates have increased in recent years in response to an aging population. Available...
Published: 9/24/2024
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Inventor(s): Charles Chan, Thomas Ambrosi, Irving Weissman, Michael Longaker, Rahul Sinha, Debashis Sahoo
Keywords(s): Hydrogel, Stem Cell
Category(s): Technology Classifications > Biology
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DESIGN OF UNIVERSAL H5 INFLUENZA VIRUS VACCINE CANDIDATES VIA ANTIGEN REORIENTATION
DESIGN OF UNIVERSAL H5 INFLUENZA VIRUS VACCINE CANDIDATES VIA ANTIGEN REORIENTATION
Researchers at Stanford University have developed novel universal vaccine candidates for H5 influenza viruses.
Influenza remains a serious threat to public health. H5 avian influenza strains are among the most concerning despite lack of documented human to human...
Published: 9/24/2024
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Inventor(s): Duo Xu, Peter Kim
Keywords(s): Immunofocusing, Vaccine
Category(s): Technology Classifications > Biology
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DIALYSIS-BASED METHOD FOR AFFINITY MAPPING OF CHROMATIN INTERACTION
DIALYSIS-BASED METHOD FOR AFFINITY MAPPING OF CHROMATIN INTERACTIONS
Researchers at Stanford have developed methods for preparing chromatin from cells for downstream genomic chromatin mapping.
Chromatin profiling strategies are widely used to map the genomic location of chromatin elements, such as histone post-translational modification and...
Published: 6/6/2024
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Inventor(s): Nicolas Altemose, Aaron Straight, Kousik Sundararajan, Nathan Gamarra
Keywords(s): Chromatin, Genomic, Mapping, Nuclear
Category(s): Technology Classifications > Biology
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HYDROGEL-ECM GRANULAR COMPOSITES WITH VISCOUS INTERSTITIUM
HYDROGEL-ECM GRANULAR COMPOSITES WITH VISCOUS INTERSTITIUM
Researchers at UCSF and CZ Biohub San Francisco have developed methods for making and using yield-stress composite matrix formulations for organoid printing.
Organoids are attractive models of health and disease as they recapture many important structural and physiological aspects of...
Published: 6/6/2024
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Inventor(s): Austin Graham, Zev Gartner, Rafael Gomez-Sjoberg
Keywords(s): Bioprinting, Organoid
Category(s): Technology Classifications > Biology
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HIGH THROUGHPUT METHOD FOR SCREENING LIPID NANOPARTICLE EFFICACY AND CYTOTOXICITY
HIGH THROUGHPUT METHOD FOR SCREENING LIPID NANOPARTICLE EFFICACY AND CYTOTOXICITY
Researchers at Berkeley have developed synthetic cell membranes that are optimized for screening the toxicity and efficacy of lipid nanoparticle formulations in vitro, in a high throughput format.
Lipid nanoparticles (LNPs) represent a highly effective and efficient...
Published: 4/22/2024
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Inventor(s): Markita Landry, Alison Lui
Keywords(s): Nanoparticle, SARS-CoV-2, Vaccine
Category(s): Technology Classifications > Biology
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