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PREDICTING 3D GENOME ARCHITECTURE FROM SINGLE-MOLECULE SEQUENCING DATA
Researchers at Stanford have developed FiberFold, a computational tool enabling the rapid analysis of 3D chromatin architecture in conjunction with chromatin accessibility, CTCF binding, CpG methylation, and underlying genetic architecture.
To gain a comprehensive understanding of the genomic regulatory landscape, it is essential to investigate various...
Published: 10/23/2025
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Inventor(s): Nicolas Altemose, Danilo Dubocanin
Keywords(s): Chromatin, Genomic, Machine Learning, Sequencing
Category(s): Technology Classifications > Biology
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MULTI-MODAL, SAME-CELL ASSAY FOR SEQUENCING AND PROTEIN DETECTION
Researchers at UC Berkeley have developed a platform that enables unified proteomic and nucleic acid-based omics analysis from the same cell.
Current multiplex assays, such as those relying on commercial systems like 10XGenomics, are limited in their ability to detect surface or intra-nuclear proteins and they require prior knowledge of target proteins...
Published: 10/23/2025
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Inventor(s): Amy Herr, Thi Thao Lam
Keywords(s): Multiplex, Nucleic Acid, Protein, Sequencing, Single Cell
Category(s): Technology Classifications > Biology
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PERILIPIN-1 SPECIFIC T CELLS FOR SELECTIVE FAT TARGETING
Researchers at UCSF and CZ Biohub SF have described cells expressing a heterologous T-cell receptor, that binds to an adipose-specific protein perilipin 1 peptide complex, thereby enabling selecting targeting of fat cells.
T cell tolerance is enforced in the thymus through the expression of a wide array of self proteins called tissue-specific antigens...
Published: 10/23/2025
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Inventor(s): Mark Anderson, Irina Proekt, Joseph DeRisi
Keywords(s): Autoantibody, Autoimmune, Therapeutic
Category(s): Technology Classifications > Biology
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ENGINEERED ANTIBODY CONSTANT REGION POLYPEPTIDES AND RELATED METHODS
Researchers at Stanford have identified amino acid modifications in the IgG Fc region which extend its therapeutic half-life and improve its in vivo receptor binding.
Biologic therapeutics, including therapeutic antibodies, that incorporate the Fc domain of antibodies are an important and growing class of drugs that have revolutionized the treatment...
Published: 10/23/2025
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Inventor(s): Varun Shanker, Soohyun Kim, Peter Kim
Keywords(s): Antibody, Fc Domain, Therapeutic
Category(s): Technology Classifications > Biology
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DELIVERY OF CRISPR COMPONENTS
Researchers at UC Berkeley have developed novel strategies for the delivery of CRISPR gene editing components.
While CRISPR-based gene editing holds great promise for treating genetic diseases, it often involves DNA breaks or base changes that can cause off-target effects, cell damage, or unpredictable outcomes. Additionally, these changes are often...
Published: 10/23/2025
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Inventor(s): James Nunez, Da Xu, Swen Besselink
Keywords(s): CRISPR, Epigenetics
Category(s): Technology Classifications > Biology
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OPTIMIZING CANCER CHEMOTHERAPY WITH THE GUT MICROBIOME
Researchers at UCSF have developed a novel innovation in harnessing the gut microbiome to alleviate severe side effects of chemotherapy.
Dose-limiting toxicities remain a significant barrier in the advancement of drug therapies, particularly in oncology. Although decades of pharmacogenomic research have identified specific human genetic variants that...
Published: 10/23/2025
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Inventor(s): Peter Turnbaugh, Chloe Atreya, Kidder Wesley, Kai Trepka
Keywords(s): Cancer, Diagnostics, Therapeutic
Category(s): Technology Classifications > Biology
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CHAGAS DISEASE SEROLOGY ANTIGEN
Researchers at CZ Biohub SF and UCSF have developed a novel diagnostic application for Chagas disease using a selective antigen.
Chagas disease is an infection caused by the parasite Trypanosoma cruzi (T. cruzi). This disease is primarily endemic to Latin America but increasingly recognized in the United States, particularly among Latinx immigrant...
Published: 10/23/2025
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Inventor(s): Jeffrey Whitman, Joseph DeRisi, Caryn Bern, Jayant Rajan, Hannah Kortbawi, Ryan Marczak
Keywords(s): Antigen, Diagnosis, Pathogen
Category(s): Technology Classifications > Biology
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ANTIBODY DIRECTED THERAPY TO PREVENT AND TREAT CHRONIC LUNG DISEASE OF INFANCY
Researchers at Stanford and CZ Biohub SF have developed a novel antibody mediated strategy for the treatment of pediatric chronic lung diseases.
Over 10% of infants worldwide are born prematurely, many of whom develop bronchopulmonary dysplasia (BPD), a serious lung disease with many comorbities. In the U.S., around 10,000 infants are diagnosed with...
Published: 10/23/2025
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Inventor(s): David Cornfield, Cristina Alvira, Stephen Quake, Carsten Knutsen
Keywords(s): Antibody, Therapeutic
Category(s): Technology Classifications > Biology
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METHODS, COMPOSITIONS, AND SYSTEMS TO DETECT NON-SMALL CELL LUNG CANCER
Researchers at CZ Biohub SF and UCSF have developed novel methods for the early detection of non-small cell lung cancer.
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths in the U.S., with many cases diagnosed at an advanced stage, significantly reducing survival rates. Although low-dose chest CT (LDCT) scans are effective...
Published: 10/23/2025
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Inventor(s): Chukwuka Didigu, Joseph DeRisi, David Jablons, Johannes Kratz, Andrew Kung
Keywords(s): Cancer, Diagnosis
Category(s): Technology Classifications > Biology
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VOLUME IMAGING OF BIOLOGICAL SPECIMENS BY PHOTOCHEMICAL SECTIONING
VOLUME IMAGING OF BIOLOGICAL SPECIMENS BY PHOTOCHEMICAL SECTIONING
Researchers at UC Berkeley and University of Illinois, Chicago have developed a nanoscale volume fluorescence imaging method that enables high-resolution imaging of large tissue volumes.
Hydrogel-based tissue clearing and expansion techniques have improved the ability to study cellular...
Published: 11/6/2024
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Inventor(s): Gokul Upadhyayula, RuiXuan Gao
Keywords(s): Hydrogel, Imaging, Photodegradable
Category(s): Technology Classifications > Biology
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