Search Results - base-modified+nucleotide

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METHOD FOR MASSIVELY PARALLEL SCREENING OF APTAMER SWITCHES

METHOD FOR MASSIVELY PARALLEL SCREENING OF APTAMER SWITCHES Researchers at Stanford have developed a massively parallel screening strategy to screen for target-responsive molecular switches. Target-responsive RNA- and DNA-based molecular switches have potential utility in a variety of technological applications. Such biosensors are typically...

Published: 3/17/2023 | Inventor(s): Hyongsok Soh

Keywords(s): Affinity Reagent, Aptamer, Base-Modified Nucleotide, Biomolecules, Biosensor System, Fluorescence, High-Throughput, Integrated Screening System, Molecular Switches, Non-Natural Nucleotide

Category(s): Technology Classifications > Biology

GENERATION AND SCREENING OF NON-NATURAL APTAMER LIBRARIES

GENERATION AND SCREENING OF NON-NATURAL APTAMER LIBRARIES Researchers at Stanford, supported in part by the Chan Zuckerberg Biohub, have developed an integrated system for the automated generation, screening, and characterization of base-modified aptamers. High affinity binding reagents have revolutionized biology and medicine. One class of synthetic...

Published: 3/17/2023 | Inventor(s): Trevor Feagin, Diana Wu, Peter Mage, John Coller, Hyongsok Soh

Keywords(s): Affinity Reagent, Aptamer, Base-Modified Nucleotide, Integrated Screening System, Machine Learning

Category(s): Technology Classifications > Biology, Technology Classifications > Chemistry