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NOVEL SMALL MOLECULE NEGATIVE ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR
NOVEL SMALL MOLECULE NEGATIVE ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR
Researchers at Stanford University and Washington University have discovered a novel molecular pathway for the treatment of opioid overdose.
Opioids are a powerful tool for pain management when used in clinical care settings. However, in recent years these drugs have...
Published: 9/24/2024
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Inventor(s): Evan Obrien, Kaavya Kumar, Brian Kobilka, Susruta Majumdar, Vipin Rangari
Keywords(s): Opiod, Pain
Category(s): Technology Classifications > Chemistry
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ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR AND CANNABINOID RECEPTOR 1
ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR AND CANNABINOID RECEPTOR 1
Researchers at Stanford have synthesized a potential novel class of pain relief drugs.
Traditional opioids, while highly effective for acute pain management, have historically been prescribed as long-term analgesic treatments despite their well-known addictive properties....
Published: 9/14/2023
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Inventor(s): Evan Obrien, Brian Kobilka, Krishna Kumar
Keywords(s): Analgesic, Opiod, Pain
Category(s): Technology Classifications > Chemistry
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COMPOSITIONS AND METHODS FOR INHIBITING FSP1
COMPOSITIONS AND METHODS FOR INHIBITING FSP1
Researchers at UC Berkeley have developed ferroptosis suppressor protein 1 (FSP1) inhibitors and methods for their use in cancer therapy.
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death that is characterized by the accumulation of oxidatively damaged phospholipids. Ferroptosis...
Published: 12/5/2024
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Inventor(s): James Olzmann, Kirill Bersuker, Julia Schaletzky, Edward Wehri, Joseph Hendricks, Cody Doubravsky
Keywords(s): Cancer, Ferroptosis, FSP1
Category(s): Technology Classifications > Chemistry
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METHODS AND COMPOSITIONS RELATED TO LANTHANIDE-ENCODED MICROBEADS
METHODS AND COMPOSITIONS RELATED TO LANTHANIDE-ENCODED MICROBEADS
Researchers at Stanford University have developed a bespoke method for multiplexing beads in bioassays that expands the possible coding space when compared to available bead barcoding technologies.
Multiplexed bioassays have drastically improved our understanding of complex biological...
Published: 3/17/2023
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Inventor(s): Yinnian Feng, Adam White, Jamin Hein, Polly Fordyce
Keywords(s): Barcoded Beads, Bioassay, Bioconjugation, Lanthanide, Microbeads, Multiplexed
Category(s): Technology Classifications > Chemistry
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CDK19- SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF
CDK19- SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF
Researchers at Stanford University have identified new CDK19-selective inhibitors for the treatment of triple negative breast cancer.
Breast cancer remains the leading cause of cancer-related mortality among women worldwide. While early cancer detection methods such as genetic biomarker screening...
Published: 3/17/2023
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Inventor(s): Robert Hsieh, Mark Smith, Michael Clarke, Vincent Alford, Andrew Amant
Keywords(s): CDK19, CDK8, Cyclin Dependent Kinases, Kinase Inhibitor, Triple Negative Breast Cancer
Category(s): Technology Classifications > Chemistry
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A METHOD OF IDENTIFYING SMALL MOLECULE INHIBITORS FOR PD-1
A METHOD OF IDENTIFYING SMALL MOLECULE INHIBITORS FOR PD-1
Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have generated a crystal structure for human PD-1 in complex with one of its ligands, PD-L2, for use in small molecule inhibitor design.
Immune checkpoint inhibition of programmed death 1 (PD-1) and its ligand 1 (PD-L1)...
Published: 12/3/2024
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Inventor(s): Shaogeng Tang, Peter Kim
Keywords(s): Crystal Structure, PD-1, PD-L1, Small Molecule Inhibitor
Category(s): Technology Classifications > Biology, Technology Classifications > Chemistry
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COMPOSITIONS AND METHODS INVOLVING NON-NATURAL APTAMER LIBRARIES
COMPOSITIONS AND METHODS INVOLVING NON-NATURAL APTAMER LIBRARIES
Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have developed Click-PD, a framework for the customizable generation of non-natural, base-modified aptamer libraries with diverse chemical modifications. These libraries are used in a high-throughput particle display...
Published: 3/17/2023
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Inventor(s): Jia Niu, Chelsea Gordon, Hyongsok Soh
Keywords(s): Aptamer, ConA, Non-Natural Nucleotide, Particle Display
Category(s): Technology Classifications > Biology, Technology Classifications > Chemistry
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GENERATION AND SCREENING OF NON-NATURAL APTAMER LIBRARIES
GENERATION AND SCREENING OF NON-NATURAL APTAMER LIBRARIES
Researchers at Stanford, supported in part by the Chan Zuckerberg Biohub, have developed an integrated system for the automated generation, screening, and characterization of base-modified aptamers.
High affinity binding reagents have revolutionized biology and medicine. One class of synthetic...
Published: 3/17/2023
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Inventor(s): Trevor Feagin, Diana Wu, Peter Mage, John Coller, Hyongsok Soh
Keywords(s): Affinity Reagent, Aptamer, Base-Modified Nucleotide, Integrated Screening System, Machine Learning
Category(s): Technology Classifications > Biology, Technology Classifications > Chemistry
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