A DEEP TISSUE ULTRASONIC IMPLANTABLE LUMINESCENCE OXYGEN SENSOR

A DEEP TISSUE ULTRASONIC IMPLANTABLE LUMINESCENCE OXYGEN SENSOR

Researchers at UC Berkeley have developed an implantable device for sensing and reporting deep-tissue oxygenation.

Tissue oxygenation is a critical determinant of organ function and can provide therapeutic guidance in health and disease prognosis. In clinical settings, tracking oxygenation is limited to indirect approaches with suboptimal utility because existing systems for monitoring tissue oxygenation are limited by the need for batteries or wired connections, the inability to provide real-time data or operation restricted to surface tissues.

Stage of Research

The inventors have developed an ultrasonic wireless implant system for continuous real-time oxygen (O2) measurements at centimeter-scale depths. Their system uses a millimeter-sized and minimally invasive, biocompatible, ultrasound-powered and wireless implantable luminescence O2 sensor and an external transceiver for bidirectional data transfer. Importantly, the inventors have developed a custom integrated circuit and single ultrasonic link protocol to enable a completely wireless and millimeter-sized (4.5 mm3) optical sensor with very low power consumption.

Applications

  • Monitoring deep-tissue oxygenation with a millimeter-scale ultrasonic implant
  • System technology can be applied to develop other biosensor systems to monitor pH or CO2

Advantages

  • Reports continuous real-time data from centimeter-scale depths
  • Ultrasound linkage allows for wireless power and data transfer, enabling efficient coupling for miniaturized implants and minimal tissue damage
  • Optimized luminescence O2 sensor has lower power consumption while maintaining competitive O2 resolution

Stage of Development

Research – in vitro

Publications

Sonmezoglu S, Fineman JR, Maltepe E, et al. Monitoring deep-tissue oxygenation with a millimeter-scale ultrasonic implant. Nature Biotechnology. 2021. Doi: 0.1038/s41587-021-00866-y

Related Web Links

https://maharbizgroup.wordpress.com/

Keywords

Biosensor, ultrasonic implant, oxygenation, luminescence, integrated circuit

Berkeley Reference

Chan Zuckerberg ref. CZB-150B, Berkeley ref. B20-048

Patent Information:
For Information, Contact:
Garima Syal
IP & Corporate Paralegal
CZ Biohub
ip@czbiohub.org
Inventors:
Soner Sonmezoglu
Michel Maharbiz
Keywords:
Biosensor
Integrated Circuit
Luminescence
Oxygenation
Ultrasonic Implant