Search for Technologies
Looking for a technology or invention to commercialize? This site has a large array of technologies listed across multiple categories that can be searched and licensed. With a direct link to universities and institutions, this is the best place to find new technologies online.
For updates when new technologies are posted, subscribe to email alerts.
VOLUME IMAGING OF BIOLOGICAL SPECIMENS BY PHOTOCHEMICAL SECTIONING
Summary: VOLUME IMAGING OF BIOLOGICAL SPECIMENS BY PHOTOCHEMICAL SECTIONING Researchers at UC Berkeley and University of Illinois, Chicago have developed a nanoscale volume fluorescence imaging method that enables high-resolution imaging of large tissue volumes. Hydrogel-based tissue clearing and expansion techniques have improved the ability to study cellular...Categories:
Biology3D PRINTING OF ORGANOID SLURRIES
Summary: 3D PRINTING OF ORGANOID SLURRIES Researchers at Stanford have developed methods for 3D printing and post-biomanufacturing of organoid slurries in a high yield stress matrix. Biomanufactured tissues and organs on demand has been a long-standing challenge in the field of tissue engineering. Despite the advancements allowed by 3D bioprinting, current...Categories:
BiologyGENETICALLY ENCODED LYSOSOME TARGETING CHIMERAS FOR CELL-MEDIATED DELIVERY
Summary: GENETICALLY ENCODED LYSOSOME TARGETING CHIMERAS FOR CELL-MEDIATED DELIVERY Researchers at Stanford have developed fully genetically-encodable lysosome-targeting chimeras which allow for the targeted delivery of various proteins into receiver cells. Lysosome-targeted degradation is an emerging therapeutic modality that facilitates the degradation...Categories:
BiologyCOMPOSITIONS AND METHODS RELATED TO CORONAVIRUS THERAPIES
Summary: COMPOSITIONS AND METHODS RELATED TO CORONAVIRUS THERAPIES Researchers at Stanford have developed fusion proteins, containing ACE2 domain linked to a fragment of non-neutralizing anti-SARS-CoV-2 spike protein antibody, with a greater breadth of protection than previously described similar fusion proteins. Coronaviruses are a large family of viruses...Categories:
BiologySELECTIVE SENSITIZATION OF CANCER CELLS TO ELIMINATION BY CYTOTOXIC LYMPHOCYTES
Summary: ­SELECTIVE SENSITIZATION OF CANCER CELLS TO ELIMINATION BY CYTOTOXIC LYMPHOCYTES Researchers at Stanford University have developed a novel method for the treatment and prevention of cancer. The immune system is an integral part of the human body’s response to outside threats, including cancer. Specifically, cytotoxic CD8+ T cells have...Categories:
BiologyCOMPOSITIONS AND METHODS FOR RE-ACTIVATION OF DYSFUNCTIONAL SKELETAL STEM CELLS
Summary: ­COMPOSITIONS AND METHODS FOR RE-ACTIVATION OF DYSFUNCTIONAL SKELETAL STEM CELLS Researchers at Stanford University have developed a novel therapeutic avenue for the treatment of osteoporosis and other musculoskeletal diseases. Musculoskeletal disease incidence rates have increased in recent years in response to an aging population. Available...Categories:
BiologyDESIGN OF UNIVERSAL H5 INFLUENZA VIRUS VACCINE CANDIDATES VIA ANTIGEN REORIENTATION
Summary: ­DESIGN OF UNIVERSAL H5 INFLUENZA VIRUS VACCINE CANDIDATES VIA ANTIGEN REORIENTATION Researchers at Stanford University have developed novel universal vaccine candidates for H5 influenza viruses. Influenza remains a serious threat to public health. H5 avian influenza strains are among the most concerning despite lack of documented human to...Categories:
BiologyNOVEL SMALL MOLECULE NEGATIVE ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR
Summary: ­NOVEL SMALL MOLECULE NEGATIVE ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR Researchers at Stanford University and Washington University have discovered a novel molecular pathway for the treatment of opioid overdose. Opioids are a powerful tool for pain management when used in clinical care settings. However, in recent years these drugs...Categories:
ChemistryDIALYSIS-BASED METHOD FOR AFFINITY MAPPING OF CHROMATIN INTERACTION
Summary: ­DIALYSIS-BASED METHOD FOR AFFINITY MAPPING OF CHROMATIN INTERACTIONS Researchers at Stanford have developed methods for preparing chromatin from cells for downstream genomic chromatin mapping. Chromatin profiling strategies are widely used to map the genomic location of chromatin elements, such as histone post-translational modification and...Categories:
BiologyMETHOD AND SYSTEM FOR FORCE SENSORS INCLUDING UPCONVERTING NANOPARTICLES IN A POLYMERIC HOST
Summary: ­METHOD AND SYSTEM FOR FORCE SENSORS INCLUDING UPCONVERTING NANOPARTICLES IN A POLYMERIC HOST Researchers at Stanford have developed force sensors that can operate on very small physical scales without the need for an external connection or power supply. Mechanical forces regulate many important biological processes from stem cell differentiation...Categories:
EngineeringHYDROGEL-ECM GRANULAR COMPOSITES WITH VISCOUS INTERSTITIUM
Summary: ­HYDROGEL-ECM GRANULAR COMPOSITES WITH VISCOUS INTERSTITIUM Researchers at UCSF and CZ Biohub San Francisco have developed methods for making and using yield-stress composite matrix formulations for organoid printing. Organoids are attractive models of health and disease as they recapture many important structural and physiological aspects of...Categories:
BiologyMETHODS FOR ULTRA-HIGH-THROUGHPUT PROFILING OF NUCLEIC ACID BINDING OR MODIFYING PROTEINS
Summary: ­METHODS FOR ULTRA-HIGH-THROUGHPUT PROFILING OF NUCLEIC ACID BINDING OR MODIFYING PROTEINS Researchers at Stanford have developed a novel method for the mapping of nucleic acid binding or modifying proteins in a massively multiplexed manner. Next generation sequencing (NGS) has allowed for sequence-agnostic sequencing and has revolutionized...Categories:
EngineeringHIGH THROUGHPUT METHOD FOR SCREENING LIPID NANOPARTICLE EFFICACY AND CYTOTOXICITY
Summary: ­HIGH THROUGHPUT METHOD FOR SCREENING LIPID NANOPARTICLE EFFICACY AND CYTOTOXICITY Researchers at Berkeley have developed synthetic cell membranes that are optimized for screening the toxicity and efficacy of lipid nanoparticle formulations in vitro, in a high throughput format. Lipid nanoparticles (LNPs) represent a highly effective and efficient...Categories:
BiologyMETHODS AND COMPOSITION FOR TARGETED RECEPTOR-MEDIATED PROGRAMMABLE MACROMOLECULE DELIVERY
Summary: ­METHODS AND COMPOSITION FOR TARGETED RECEPTOR-MEDIATED PROGRAMMABLE MACROMOLECULE DELIVERY Researchers at Stanford have developed a novel method for programmable macromolecule delivery via engineered cells, using trogocytosis. Genome editing technologies have revolutionized the field of personalized medicine. Despite its initial promise,...Categories:
BiologyDROPLET-ELECTROPHORESIS DEVICES AND RELATED METHODS
Summary: ­DROPLET-ELECTROPHORESIS DEVICES AND RELATED METHODS Researchers at UC Berkeley have developed a novel method for comprehensively profiling the proteomes of single cells. Genomics (DNA) and transcriptomics (RNA) sequencing is one of the cornerstones of our modern-day understanding of the genetic blueprint of life. Furthermore, sequencing...Categories:
EngineeringNON-INVASIVE PROFILING OF URINARY TRACT TISSUES WITH URINE LIQUID BIOPSY
Summary: ­NON-INVASIVE PROFILING OF URINARY TRACT TISSUES WITH URINE LIQUID BIOPSY Researchers at Stanford and UCSFhave determined methods of performing cell-free RNA (cfRNA) transcriptomics and metabolomics on urine samples. Urine is assayed alongside blood in medicine, however current clinical diagnostic tests exploit only a minor fraction of its biomolecular...Categories:
BiologyGENERATION OF ANTIGEN-SPECIFIC T AND B CELLS USING ENGINEERED COMMENSALS
Summary: ­GENERATION OF ANTIGEN-SPECIFIC T AND B CELLS USING ENGINEERED COMMENSALS Researchers at Stanford have developed methods to link antigenic or immunomodulatory molecules to bacterial surface proteins of commensal bacteria that result in a high immune response when applied to an epithelial surface of a mammal. Commensal microbiota reside primarily...Categories:
BiologyCELL-PENETRATING PEPTIDES FOR NUCLEIC ACID AND PROTEIN DELIVERY IN PLANTS
Summary: ­CELL-PENETRATING PEPTIDES FOR NUCLEIC ACID AND PROTEIN DELIVERY IN PLANTS Researchers at UC Berkeley have developed methods to deliver biomolecules to plant cells using new plant-derived cell penetrating peptides (CPPs). Despite the revolution in DNA editing that the last decade has brought, plant genetic engineering has not been able to benefit...Categories:
BiologyMANIPULATING SPATIAL RNA LOCALIZATION
Summary: ­MANIPULATING SPATIAL RNA LOCALIZATION Researchers at Stanford have developed an inducible and programmable CRISPR-mediated transcript organization (CRISPR-TO) method for repositioning RNAs to various desired subcellular compartments. Spatial RNA transcriptomics, including subcellular mRNA localization, is a core mechanism for spatiotemporal regulation...Categories:
BiologyDESIGN OF A UNIVERSAL INFLUENZA VACCINE CANDIDATES VIA ANTIGEN REORIENTATION
Summary: ­DESIGN OF A UNIVERSAL INFLUENZA VACCINE CANDIDATES VIA ANTIGEN REORIENTATION Researchers at Stanford have developed a novel universal influenza vaccine candidate. Vaccines are a major feat of biomedical innovation. Successful vaccines produce broad humoral immunity to a pathogen to prevent subsequent infection. In this vein, adjuvants are...Categories:
Biology